The Antiproliferative, Antioxidant Activities and Toxicity of Mixed-Ligand Amine-Containing Copper (II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(Prop-2-En-1-Yl) Hydrazinecarbothioamide

Garbuz Olga; Toderash Ion; Ulchina Ianina; Graur Vasilii О.; Railyan Nadejda; Gulya Aurelian

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2024-04-01 08:23

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Ecologie generală şi biodiversitate (779)

Tehnici biologice, echipament şi metode experimentale în general (194)

Analiză, investigae și manipulare în general (25)

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GARBUZ, Olga, TODERASH, Ion, ULCHINA, Ianina, GRAUR, Vasilii О., RAILYAN, Nadejda, GULYA, Aurelian. The Antiproliferative, Antioxidant Activities and Toxicity of Mixed-Ligand Amine-Containing Copper (II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(Prop-2-En-1-Yl) Hydrazinecarbothioamide. In: Sustainable use and protection of animal world in the context of climate change: dedicated to the 75th anniversary from the creation of the first research subdivisions and 60th from the foundation of the Institute of Zoology, Ed. 10, 16-17 septembrie 2021, Chișinău. Chișinău: Institutul de Zoologie, 2021, Ediția 10, pp. 123-129. ISBN 978-9975-157-82-7. DOI: https://doi.org/10.53937/icz10.2021.20

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Sustainable use and protection of animal world in the context of climate change
Ediția 10, 2021

Conferința "Sustainable use and protection of animal world in the context of climate change"
10, Chișinău, Moldova, 16-17 septembrie 2021

The Antiproliferative, Antioxidant Activities and Toxicity of Mixed-Ligand Amine-Containing Copper (II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(Prop-2-En-1-Yl) Hydrazinecarbothioamide

DOI:https://doi.org/10.53937/icz10.2021.20

CZU: [574.64+574.62]:57.084+54.06

Pag. 123-129

Garbuz Olga¹², Toderash Ion¹, Ulchina Ianina², Graur Vasilii О.², Railyan Nadejda¹, Gulya Aurelian²

¹ Institute of Zoology,
² Moldova State University

Proiecte:

Menționat în lucrare: 20.80009.7007.12 Diversitatea artropodelor hematofage, a zoo şi fitohelminţilor, vulnerabilitatea, strategiile de tolerare a factorilor climatici şi elaborarea procedeelor inovative de control integrat al speciilor de interes socio-economic

Menționat în lucrare: 20.80009.7007.23 Identificarea, evaluarea şi perfecţionarea unor noi procedee de sporire a ratei de creştere a peştilor, de diminuare a impactului maladiilor şi de îmbunătățire a valorificării furajelor în cadrul instalaţiilor piscicole de tip închis alimentate cu apă circulantă

Disponibil în IBN: 17 septembrie 2021

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Rezumat

Five compounds 2-(2-Hydroxybenzylidene)-N-(prop-2-en1-yl)hydrazinecarbothioamide (H2L), bis[μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl) phenolatoS,N,O:O] diaquadicopper (II) nitrate (1), bis [μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl)phenolato-S,N,O:O]d iimidazoldicopper(II) nitrate (2), bis[μ2-2-({2-[(prop-2en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper( II) nitrate hexahydrate (3), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl) phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds towards cancer cell lines HeLa, RD and normal cell line MDCK have been investigated. The tested compounds demonstrated high antioxidant and antiproliferative, selective activities towards cancer cells. Direct toxic evaluation of compounds was performed by Daphnia magna bioassay.