Cutaneous tumors of mesenchymal origin are a heterogeneous group of neoplasms that show a broad range of differentiation and are classified histologically according to the mature tissue they resemble. These heterogeneous mesenchymal neoplasms are relatively uncommon and little is known regarding their etiology or incidence patterns. To the authors’ knowledge, no prior large, population-based study has focused on these tumors in the Republic of Moldova. In our study we have analyzed the incidence patterns of cutaneous tumors of mesenchymal origin and observed distinctive differences among the various histologic types.