The European legislative on the use of different control strategies against plant-parasitic nematodes, with particular reference to pesticides, is constantly evolving, sometimes causing confusion in the sector operators. This article highlights the nematode control management allowed in the C Zone of the European Union, which includes the use of chemical nematicides (both fumigant and non-fumigant), agronomic control strategies (crop rotations, biofumigation, cover crops, soil amendments), the physical method of soil solarization, the application of biopesticides (fungi, bacteria and their derivatives) and plant-derived formulations. The authors analyze the use of these strategies and substances in organic agriculture as well as in Integrated Pest Management (IPM) programs.