This article presents the challenges and the perspectives for entrepreneurship development in European countries in the covid pandemic conditions. The research consists of the comparative analysis of statistical data of the entrepreneurial activity and confirm the differences in this activity at European level during the crisis. The article exposed some difficulties of businesses to the development of electronic markets in European Union countries: difficulties of taxation, of customs and transport, differences between countries in the legal framework, fragmentation in the industry, difficulties of small businesses, insufficient appropriate marketing strategies, differences in culture and language.