Mechanisms of crop plants resistance to invasive organisms can be specific or nonspecific, according to Van der Planck (1981), where the host-pathogen pathosystem is more often vertical or specific, based on genes present in both partners, as well as specific metabolites encoded by them. The interaction in the interactive pathosystem causes a predominantly induced immune response, selective in certain plant genotypes, and the relationship in horizontal-nonspecific pathosystems is determined by the genetic mechanisms responsible for plant resistance to parasitic organisms. The specific relationship between parasitic nematode and plant complexes is associated with the presence of genes that determine the resistance of the host plant to invasive attack, and the genetic basis of the relationship between plants and nematodes has been studied in only a few pathos related to invasive gallic and cyst-forming species of the genera: Meloydogine spp., Heterodera spp., and Globodera spp. (Ocopnii N. and col., 1975-2000). The resulting research on the evidence, structure and functions of genes that determine specific resistance to nematodes has been successful in determining the Mi gene present in tomatoes, responsible for resistance to gallic nematodes Meloidogyne spp. (Ho K. and col., 1992). Subsequently, when cloning the genes that determine the resistance to nematodes, it was established that they belong to the NBS-LRR class, which also includes genes responsible for the resistance of plants to viruses, bacteria and fungi. Thus, the Mi gene, which determines the resistance of tomatoes to nematodes, is similar to the fungal resistance genes - Cf2 and Cf5 and to the Meu1 gene, which determines the resistance to aphids. The esteemed genes encoding potato resistance to golden cyst-forming nematodes of the genus Globodera spp. Are similar to the Rx gene, which determines resistance to viruses, including other resistance genes to cyst-forming nematodes of the genus Heterodera spp. (Ocopnii N. and col., 1987, Williamson V. and Glason C., 2003, Ryss A. I. 2009, Subbotin S. and col., 2012). The study of genes that determine the resistance of plants to nematodes with high invasive potential, showed that each gene is a complex locus, which encodes several similar or identical proteins, from a structural point of view, and in the relationships of the parasite-host system, the resistance gene plant corresponds to the parasite virulence gene, with evidence that estimates the presence of avirulent genes in the invasive species Globodera rostochiensis, which also corresponds to the plant resistance gene - H1. Genetic analysis of strains with reference to cyst-forming nematodes, identifies the action of dominant and recessive determinants of parasitism in annual technical plants and vegetables