Identification and studying of the scientific articles publicly available, concerned with the technological procedures of the in situ DNA methylation profiles variability estimation, and formulation of an algorithm to be used in the prediction of the DNA methylation determined normal or pathological metabolic processes at the cellular level in animals and human. For the literature search, there were used the internet facility, https://pubmed.ncbi.nlm.nih.gov, and the key-words Whole-Mount-MeFISH, plus BISmark, cellular heterogeneity, cellular differentiation and cellular reprogramming. At the next step, there were selected literature sources that refered to the possibilities of the in situ DNA methylation profiles variability estimation in heterogenous cellular samples which contained cells at various functional and differentiation degrees. Subsequently, a narrative synthesis of the two complementary technological procedures was done. Original articles were identified which stated innovative methods of visualization of the methylated DNA sequences in intact (in situ) animal or human cells. Also, there were made references to a serie of publications that supported the valability of entropy criteria for the precise estimation (specifically for each cellular differentiational subtype) of the DNA methylation profiles (methylomes) variability in heterogenous cellular populations (mixtures) and the success of BISmark molecular mapping implementation in the characterizing of DNA methylation profiles at various epigenetic and functional stages during in vitro cell cultures of differentiated human adipocites, human adipose-derived stem cells and human induced pluripotent stem cells. The Whole-Mount-MeFISH-BISmark narrative synthesis of the two complemenary technological procedures, is formulated as an innovative, multipurpose operational research instrument. It is formulated the Whole-Mount-MeFISH-BISmark algorithm for the in situ DNA methylation profiles variability estimation, to be used in the prediction of the DNA methylation determined normal or pathological metabolic processes at the cellular level in animals and human.