EARLY versus MILD Chronic Obstructive Pulmonary Disease (COPD)
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SIAFAKAS, Nikolaos M., BIZYMI, Nikoleta, MATHIOUDAKIS, Alexander G., CORLĂTEANU, Alexandru. EARLY versus MILD Chronic Obstructive Pulmonary Disease (COPD). In: Respiratory Medicine, 2018, nr. 140, pp. 127-131. ISSN 0954-6111. DOI: https://doi.org/10.1016/j.rmed.2018.06.007
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Respiratory Medicine
Numărul 140 / 2018 / ISSN 0954-6111 /ISSNe 1532-3064

EARLY versus MILD Chronic Obstructive Pulmonary Disease (COPD)

DOI: https://doi.org/10.1016/j.rmed.2018.06.007

Pag. 127-131

Siafakas Nikolaos M.1, Bizymi Nikoleta1, Mathioudakis Alexander G.2, Corlăteanu Alexandru3
 
1 University of Crete Medical School, Crete,
2 University of Manchester,
3 ”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 11 iunie 2021


Rezumat

Chronic Obstructive Pulmonary Disease (COPD) is very a common, with great morbidity and mortality, disease. Since the beginning of the disease cannot be detected with precision and by using only FEV1 to monitor the evolution of the disease, the Natural History of COPD is rather obscure and sometimes controversial. Therefore, the terms EARLY COPD and MILD COPD have been used indistinguishably in the medical literature. In this review we discuss the two terms trying to clarify some of the definition issues, starting with a synopsis of the Naturel History of the disease. We recommend to use the term EARLY COPD for the pre-clinical stage of the disease (stage 0) and the term MILD COPD when the diagnosis is confirmed by spirometry and FEV1 is above 80% predicted. However, COPD is a complex disease and spirometric evaluation alone (MILD COPD, stage I), cannot fully describe the clinical status of the patient. We conclude that biomarkers to detect the starting point and been able to follow the natural history of the disease more accurately, beyond FEV, are urgently needed.

Cuvinte-cheie
Airflow limitation, Beginning of COPD, Chronic bronchitis, clinical, emphysema, natural history, Pre-clinical, Sub-clinical