Since ancient times, agriculture has been the essential pillar in the development of the society. Along with industrialization, the approach on the production of agricultural crops changed. With the increase in population, the need for food has also increased. This has led to the implementation of pest control strategies, by applying various treatments, obtained synthetically in the laboratory, but with side effects for both the environment and human health. If modern agriculture has undergone many changes at the current level, it is necessary that the approaches used to control pest to be kept in check with agricultural production on the one hand, and also with the impact of treatments on the environment and population health. This paper aims to present a new view on pest control by replacing synthetic pesticides with biopesticides from spontaneous flora of Moldova area (Romania). The plants considered to have potential in keeping pests under control are: Primula veris, Origanum vulgare, Artemisia absinthium and Achillea millefolium, respectively. Therefore, the paper focuses on using environmentally friendly extraction methods and extractants, and with a promising effect on crop and storage pests (Leptinotarsa decemlineata Say and Acantoscelides obsoletus) for selected agricultural crops (potatoes and beans). Comparative studies were performed between different extraction methods (ultrasound assisted extraction (UAE), heat assisted extraction (HAE), maceration (M), the combined UAE + M methods) and different extraction agents (hydro-alcoholic solution (50%, 70% ethanol) and ethyl alcohol with 96% concentration, respectively). The extraction was studied in the conditions in which a series of parameters were modified: temperature, process time, S / L ratio and properties of extraction agents. The obtained extracts were analyzed from a quantitative point of view by determining the content of total polyphenols and flavonoids and the efficiency was assessed after the value of the extraction degree. The highest extraction degrees were obtained by the combined method (UAE + M) followed by the UAE method using a concentration of 1:1 ethanol: water. Similar results were obtained in the case of HAE and M methods. In conclusion, the plant extracts obtained by using environmentally friendly extraction methods and spontaneous flora plants, represent an modern and ecological alternative in controlling crop and storage pests of L. decemlineata Say and A. obsoletus species. Efficiency of plant extracts could be improved by combining with other sustainable agriculture strategies and they are recommended especially for small farmers who embrace the concept of organic crops.