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Ultima descărcare din IBN: 2023-05-28 11:43 |
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547:577:66 (1) |
Chimie organică (475) |
Bazele materiale ale vieții. Biochimie. Biologie moleculară. Biofizică (655) |
Tehnologie chimică. Industrii chimice și înrudite (1496) |
SM ISO690:2012 GÎRBU, Vladilena, UNGUR, Nikon, RENAUD, Philippe, KULCIŢKI, Veaceslav. Free radical functionalizations of labdanes and related diterpenoids. In: New frontiers in natural product chemistry.: A destiny on the altar of research. Dedicated to academician Pavel Vlad, Ed. 6, 21 mai 2021, Chișinău. Chișinău, Republica Moldova: Tipografia "Artpoligraf", 2021, Ediția 6, p. 27. ISBN 978-9975-3336-7-2. DOI: https://doi.org/10.19261/nfnpc.2021.ab20 |
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New frontiers in natural product chemistry. Ediția 6, 2021 |
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Conferința " New frontiers in natural product chemistry." 6, Chișinău, Moldova, 21 mai 2021 | |
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DOI: https://doi.org/10.19261/nfnpc.2021.ab20 | |
CZU: 547:577:66 | |
Pag. 27-27 | |
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Free radical transformations are intensively explored nowadays as efficient synthetic tools provided the broad range of potential transformations, mild reaction conditions and high functional group tolerance. Synthesis and structural modification of natural products provide a fruitful field for atom transfer radical addition (ATRA) methodology and in our opinion this potential is underexplored. There is still prevalence in the scientific publications of ionic processes reported for assembling C-C bonds in complex molecular frameworks, although successful examples involving ATRA are also known in natural product synthesis [1]. Sometimes radical additions represent the only solutions to overcome synthetic challenges connected to substrate reactivity and stereochemistry issues [1]. Figure 1. Radical transformation of labdane diterpenoids. ent-Kauranic, isocopalic and labdane derivatives (Figure 1) were modified via ATRA processes. An array of functionalized derivatives, including azides and fluorinated compounds have been obtained in good yields and will be further involved in biological activity testing. |
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