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Articolul urmator |
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SM ISO690:2012 CALANCEA, Sergiu, LOZAN, Ecaterina, SIVIREAN, Elena. Synthesis of new derivatives of 2,2’-(1,2(3 or 4)-phenylen)bis-[1,3-dioxolane-4r,5r(+)-4,5- diethoxicarboxylic] acids. In: International Conference of Young Researchers , Ed. 8, 11-12 noiembrie 2010, Chişinău. Chişinău: Tipogr. Simbol-NP SRL, 2010, Ediția 8, p. 76. ISBN 978-9975-9898-4-8.. |
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International Conference of Young Researchers Ediția 8, 2010 |
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Conferința "International Conference of Young Researchers " 8, Chişinău, Moldova, 11-12 noiembrie 2010 | ||||||
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Pag. 76-76 | ||||||
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There are variety of biologically active substances obtained from the R,R-(+)-tartaric acid which shows the antimicrobials[1] and antifungicals[2][3] properties, that encourages our research in this direction. Previous studies of chiral bis-hydrazones of (4-R,5-R)-2-aryl-1,3-dioxolane-4,5-dicarboxylic acids show selective bactericidal and fungicidal properties (1)[4]. For these reasons, is important the synthesis of new tetra-hydrazones which contains two dioxolane cycles (2c) thus making possible duplication of bioactive groups. The esters (2a) are obtained by condensation (R,R)-2,3-bis(O-trimethylsilyl)tartrate with aromatic dialdehyde[5]. The next stage is to obtain tetra-hydrazides (2b) by treatment of esters (2a) with hydrazine. The last step is condensation of tetrahydrazides (2b) with aromatic dialdehydes. The structures of compounds obtained were confirmed by IR, 1H-NMR and 13C-NMR spectra. |
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Cuvinte-cheie R, R-( )-tartaric acid, bactericidal, fungicidal, tetra-hydrazones. |
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Cerif XML Export
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