Experimental substantiation of hyperthermic exogenous and endogenous factors prompt neutralization in burn injuries
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616-001.17:614.88:612.8 (1)
Patologie. Medicină clinică (3962)
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CHORNOPYSHCHUK, Roman. Experimental substantiation of hyperthermic exogenous and endogenous factors prompt neutralization in burn injuries. In: Moldovan Medical Journal. 2021, nr. 2(64), pp. 53-57. ISSN 2537-6373.
10.52418/moldovan-med-j.64-2.21.10
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Moldovan Medical Journal
Numărul 2(64) / 2021 / ISSN 2537-6373 /ISSNe 2537-6381

Experimental substantiation of hyperthermic exogenous and endogenous factors prompt neutralization in burn injuries


CZU: 616-001.17:614.88:612.8
DOI: 10.52418/moldovan-med-j.64-2.21.10
Pag. 53-57

Chornopyshchuk Roman
 
National Pirogov Memorial Medical University, Vinnytsya
 
Disponibil în IBN: 4 mai 2021


Rezumat

Background: High mortality and disability of patients with critical and supercritical burns, long-term treatment, unsatisfactory aesthetic and functional results lead to the search for ways to provide assistance aimed at counteracting the formation of a mass of necrotic tissue, which is crucial for life or death of the victim. Material and methods: The experimental study was performed on 60 sexually mature Wistar rats, which were on a regular diet and weighed 150-160 g. The experimental animals were divided into the main and control groups and were used to simulate burns with boiling water of IIb degree. Results: The traumatic effect of hyperthermic exogenous and endogenous damage factors of the animals in the main group were immediately neutralized by a gauze napkin soaked in water at a temperature of 18-20 °C immediately after the simulation of burns, the duration of which became the criterion for dividing them into subgroups. In animals of subgroup 1 the time of application of a wet wipe to the burn area was 1 min., in the 2nd subgroup it was 5 min., 3rd subgroup – 10 min., 4th subgroup – 15 min., 5th subgroup – 20 min. The application napkin was changed when it was heated to 34 °C. Such applications were not performed to the animals of the control group. Conclusions: The conclusion was made on the necessity of prompt neutralization of traumatic action of hyperthermic exogenous and endogenous damage factors as the main elements of burn wound depth. For a broader understanding of action mechanisms of the suggested technology of self-help and mutual

Cuvinte-cheie
hyperthermic factors, burns, neutralization, first aid, necrotic tissues