Posible differential diagnosis of various chronic nonbacterial prostatites
Închide
Conţinutul numărului revistei
Articolul precedent
Articolul urmator
389 6
Ultima descărcare din IBN:
2023-11-15 15:10
Căutarea după subiecte
similare conform CZU
616.65-002.2-079.4 (1)
Patologia sistemului urogenital. Boli urinare şi sexuale (genitale) (368)
SM ISO690:2012
COLȚA, Artur. Posible differential diagnosis of various chronic nonbacterial prostatites. In: Moldovan Medical Journal, 2021, nr. 2(64), pp. 33-36. ISSN 2537-6373. DOI: https://doi.org/10.52418/moldovan-med-j.64-2.21.06
EXPORT metadate:
Google Scholar
Crossref
CERIF

DataCite
Dublin Core
Moldovan Medical Journal
Numărul 2(64) / 2021 / ISSN 2537-6373 /ISSNe 2537-6381

Posible differential diagnosis of various chronic nonbacterial prostatites

DOI: https://doi.org/10.52418/moldovan-med-j.64-2.21.06
CZU: 616.65-002.2-079.4

Pag. 33-36

Colța Artur
 
”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 4 mai 2021


Rezumat

Background: The purpose of the study was to diagnose possible chronic nonbacterial prostatitis (CNP) and chronic pelvic pain syndrome (CPPS) among patients, as well as differentiate between the inflammatory (category IIIA) or non-inflammatory (category IIIB) types in selecting and optimizing differential drug treatment of this category of patients. Material and methods: The study was conducted on 43 patients diagnosed with CNP/CPPS. The control group included 10 healthy men. Both the production of nitric oxides (NO) by phagocytes, as well as prostate secretion and ejaculate were determined according to the procedure described by Metelyskaya B.A., which was modified by Gudumac V, et al. Results: There was a 39.0% (p <0. 05) decrease in NO production by induced NO-synthase (iNOS), determined in the blood of 11 patients (from the main group – 2) with CNP/CPPS and a 115% (p <0.05) increase was determined in 32 patients (from the main group 1) if compared to the same indices in the control group. The prostatic secretion and ejaculate showed a higher macrophage iNOS activity by 80% (p <0.05) and 75% (p <0.05) if compared to the same parameters from the control group. The iNOS activity in prostatic fluid and split-ejaculate fractions from the main group – 2 did not differ from that of the control group. Conclusions: The assessment of NO production, prostate secretion and ejaculate allows to somewhat establish the main diagnosis of CNP and category III types (A – inflammatory and B – non-inflammatory prostatitis), which will significantly contribute to the optimization and selection of an appropriate differential treatment based on the drug action mechanisms.

Cuvinte-cheie
chronic nonbacterial prostatitis, nitric oxide, chronic painful pelvic syndrome, drugs

DataCite XML Export

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xmlns='http://datacite.org/schema/kernel-3' xsi:schemaLocation='http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd'>
<identifier identifierType='DOI'>10.52418/moldovan-med-j.64-2.21.06</identifier>
<creators>
<creator>
<creatorName>Colța, A.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='en'>Posible differential diagnosis of various chronic nonbacterial prostatites</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2021</publicationYear>
<relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>2537-6373</relatedIdentifier>
<subjects>
<subject>chronic nonbacterial prostatitis</subject>
<subject>nitric oxide</subject>
<subject>chronic painful pelvic syndrome</subject>
<subject>drugs</subject>
<subject schemeURI='http://udcdata.info/' subjectScheme='UDC'>616.65-002.2-079.4</subject>
</subjects>
<dates>
<date dateType='Issued'>2021-05-03</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Journal article</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'><p>Background: The purpose of the study was to diagnose possible chronic nonbacterial prostatitis (CNP) and chronic pelvic pain syndrome (CPPS) among patients, as well as differentiate between the inflammatory (category IIIA) or non-inflammatory (category IIIB) types in selecting and optimizing differential drug treatment of this category of patients. Material and methods: The study was conducted on 43 patients diagnosed with CNP/CPPS. The control group included 10 healthy men. Both the production of nitric oxides (NO) by phagocytes, as well as prostate secretion and ejaculate were determined according to the procedure described by Metelyskaya B.A., which was modified by Gudumac V, et al. Results: There was a 39.0% (p &lt;0. 05) decrease in NO production by induced NO-synthase (iNOS), determined in the blood of 11 patients (from the main group &ndash; 2) with CNP/CPPS and a 115% (p &lt;0.05) increase was determined in 32 patients (from the main group 1) if compared to the same indices in the control group. The prostatic secretion and ejaculate showed a higher macrophage iNOS activity by 80% (p &lt;0.05) and 75% (p &lt;0.05) if compared to the same parameters from the control group. The iNOS activity in prostatic fluid and split-ejaculate fractions from the main group &ndash; 2 did not differ from that of the control group. Conclusions: The assessment of NO production, prostate secretion and ejaculate allows to somewhat establish the main diagnosis of CNP and category III types (A &ndash; inflammatory and B &ndash; non-inflammatory prostatitis), which will significantly contribute to the optimization and selection of an appropriate differential treatment based on the drug action mechanisms.</p></description>
</descriptions>
<formats>
<format>application/pdf</format>
</formats>
</resource>