Alpha-1 antitrypsin deficiency and chronic obstructive pulmonary disease: Between overlaps, phenotypes and illnesses
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CORLĂTEANU, Alexandru, COVANTSEV, Serghei, CARAIVANOVA, Irina, BODRUG, Vlada, BOTNARU, Victor, VARON, Joseph, SIAFAKAS, Nikolaos M.. Alpha-1 antitrypsin deficiency and chronic obstructive pulmonary disease: Between overlaps, phenotypes and illnesses. In: Current Respiratory Medicine Reviews, 2019, nr. 2(15), pp. 147-155. ISSN 1573-398X. DOI: https://doi.org/10.2174/1573398X15666190617143122
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Current Respiratory Medicine Reviews
Numărul 2(15) / 2019 / ISSN 1573-398X

Alpha-1 antitrypsin deficiency and chronic obstructive pulmonary disease: Between overlaps, phenotypes and illnesses

DOI:https://doi.org/10.2174/1573398X15666190617143122

Pag. 147-155

Corlăteanu Alexandru1, Covantsev Serghei1, Caraivanova Irina1, Bodrug Vlada1, Botnaru Victor1, Varon Joseph2, Siafakas Nikolaos M.3
 
1 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
2 The University of Texas Medical Branch at Galveston, Houston,
3 University General Hospital of Heraklion
 
 
Disponibil în IBN: 21 aprilie 2021


Rezumat

Alpha-1 antitrypsin deficiency (AATD) or alpha-1 antitrypsin proteinase inhibitor (α1-Pi) deficiency, is a genetic disorder leading to a higher risk of pulmonary, hepatic and other organ-related diseases. The spectrum of diseases associated with AATD is large and includes pulmonary conditions (COPD, asthma, asthma-COPD overlap syndrome, bronchiectasis, etc.) as well as extrapulmonary (liver diseases, systemic vasculitis, rheumatoid arthritis, panniculitis, multiple sclerosis, peripheral neuropathy). We present a review of AATD focusing on its connection to other conditions.

Cuvinte-cheie
Alpha-1 antitrypsin deficiency, bronchiectasis, COPD, illness, Phenotypes, syndrome