Introducere. S-a constatat că atunci cînd se utilizează medicamente şi se îngeră accidental sau se face abuz de alcool, au apărut reacţii similare cu simptomele menţionate în tratamentul alcoolismului cu disulfiram.
Scopul lucrării. Analiza literaturii şi selectarea medicamentelor responsabile de producerea unor reacţii de tip disulfiram.
Material şi metode. Studiul literaturii ştiinţifice pentru evidenţierea grupelor de preparate şi reprezentanţii acestora care la utilizarea concomitentă cu alcoolul produc reacţii nedocrite de tip disulfiram.
Rezultate. Studiul literaturii ştiinţifice a relevat că reacţii de tip disulfiram pot provoca următoarele grupe şi medicamente: antivirale (abacavir), cefalosporine (cefamandol, cefonicid, cefoperazonă, ce-fotetan, ceftriaxon, cefuroxim), amfenicoli (cloramfenicol), sulfamide combinate (co-trimoxazol), anti-fungice (griseofulvina, ketoconazol), antituberculoase (derivaţii hidrazinici, procarbazina), derivaţii de nitrofuran (furazolidona, nitrofurantoina), dervaţii de nitroimidazol (metronidazol, ornidazol, tinidazol, benznidazol), antiprotozoice (mepacrina), nitraţii organici (nitroglicerina), diuretice (acid etacrinic), imunodepresive (pimecrolimus, tacrolimus), antiandrogenii (nilutamida), analgezice-antipiretice (fena-cetina), antiinflamatoare nesteroidiene (fenilbutazona), alfa-adrenoblocante (fentolamina, tolazolina), beta-adrenoblocante (propranolol), sulfoniluree antidiabetice (clorpropamida, glibenclamida, glibu-rida), biguanidele (metformina).
Concluzii. Medicamentele evidenţiate la utilizarea accidentală a alcoolului şi, îndeosebi, în cazul abuzului de alcool pot fi responsabile de reacţii nedorite de tip disulfiram, fapt ce necesită a fi luate în considerare de medicii de diferite specialităţi.

Introduction. It was found that when using, ingesting drugs accidentally or abusing alcohol, occured similar reactions with the stated symptoms in the treatment of alcoholism with disulphiram.
Objective of the study. Literature analysis and selection of drugs responsible for the production of disulphiram-type reactions.
Material and methods. The study of scientific literature to highlight groups of drugs and their representatives that, when used concomitantly with alcohol, produce undesirable reactions of the disulphiram type.
Results. The study of the scientific literature has shown that disulphiram-type reactions can cause the following groups and drugs: antivirals (abacavir), cephalosporins (cefamandol, cefonicide, cefoperazone, cefotetan, ceftriaxone, cefuroxime), amphenicols (chloramphenicol), combined sulfamides (co-trimo-xazole) antifungals (griseofulvin, ketoconazole), antituberculous (hydrazine derivatives, procarbazine), nitrofuran derivatives (furazolidone, nitrofurantoin), nitroimidazole derivatives (metronidazole, orni-dazole, tinidazole, benznidazole), antiprotozoic (mepacrine), organic nitrates (nitroglycerin), diuretic (etacrynic acid), antidepressants (pimecrolimus, tacrolimus), antiandrogens (nilutamide), analgesic-anti-pyretic drugs (phenacetin), non-steroidal anti-inflammatory drugs (phenylbutazone), alpha-adreno-blockers (phentolamine, tolazoline), beta-adrenoblockers (propranolol), antidiabetic sulfonylureas (chlorpropamide, glybenclamide, glyburide), biguanides (metformin).
Conclusions. Medicines highlighted for accidental use of alcohol and, particularly, for alcohol abuse may be responsible for undesirable disulphiram reactions, which need to be considered by doctors of different specialties.