Articolul precedent |
Articolul urmator |
310 9 |
Ultima descărcare din IBN: 2023-12-21 16:59 |
SM ISO690:2012 VÎRLAN, Victoria, MAZUR, Ecaterina, VALICA, Vladimir, ZARA, Inga, UNCU, Livia. Aplicarea cromatografiei pe strat subțire pentru identificarea ciprofloxacinei și econazolului în combinație . In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 688. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | |||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | |||||
|
|||||
Pag. 688-688 | |||||
|
|||||
Descarcă PDF | |||||
Rezumat | |||||
Background. Thin layer chromatography (TLC) allows the separation of substances from the mixture and has been used for the analysis of the combination of ciprofloxacin (antimicrobial from the fluoroquinolone group) and econazole (antifungal, imidazole derivative). Objective of the study. Separation and identification of ciprofloxacin and econazole in combination by TLC, selection of suitable solvents for the detection of both substances in combination. Material and Methods. pharmaceutical substances ciprofloxacin hydrochloride and econazole nitrate (Sigma Aldrich, USA), chromatographic plates "Silufol", chromatography chamber, solvents, reagents according to the European Pharmacopoeia. Results. Of the 28 chromatographic systems with different polarity investigated, the solvent mixture Methanol: Acetonitrile (40:60) is the optimal mobile phase for both substances, as it forms well-defined spots and achieves a good separation of components. After chromatography, the plates were sprayed with Dragendorf reagent and examined in UV light at a wavelength of 254 nm (fluorescence and yellow-orange spots). For ciprofloxacin hydrochloride Rf = 0.32, and for econazole nitrate Rf = 0.77. Conclusion. The working technique developed for the separation of ciprofloxacin and econazole in combination by TLC can be used to identify substances in the same pharmaceutical form. |
|||||
Cuvinte-cheie TLC, ciprofloxacin hydrochloride, econazole nitrate, CSS, clorhidrat de ciprofloxacină, nitrat de econazol |
|||||
|