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SM ISO690:2012 UNCU, Livia, CARMAZAN, Sabina, VALICA, Vladimir, PODGORNÎI, Ana, VÎSLOUH, Oxana, DONICI, Elena. Separarea cromatografică pe strat subțire a izohidrafuralului și metiluracilului în combinație mecanică și picături auriculare . In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 686. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 686-686 | ||||||
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Background. The combined ear drops represent an advantage over the monocomponent ones due to their polyvalent action. The thin layer chromatography (TLC) method is used to separate the active principles. Objective of the study. Separation and identification of isohydrafural and methyluracil in mechanical combination and pharmaceutical form by TLC. Material and Methods. Experimental series of isohydrafural (IHF), methyluracil (MU) (Sigma Aldrich, USA), chromatographic plates "Silufol", chromatography chamber, solvents, reagents according to the European Pharmacopoeia. Results. Mobile phases were used: chloroform-acetone (70:30), 1-butanol-diethyl ether-acetone (10:85:5), ethyl acetate-hexane (2:1), glacial acetic acid-water-butanol (1:1) 1:4), chloroform-methanolglacial acetic acid (90:8:8 and 95:10:2). During the analyzes, 4 working techniques were used with the detection of spots in UV light at different wavelengths, spraying with pyridine and pdimethylaminobenzaldehyde solutions. The mobile phase ethyl acetate-hexane (2:1) was selected for the qualitative analysis of the compounds in mechanical mixture (I) and the pharmaceutical form (II). The values of the retention factors are: I-IHF-Rf = 0,37; MU-Rf = 0,72 and II-IHF-Rf = 0,35; MU-Rf = 0,70. Conclusion. The elaborated working technique will be included in the quality specification of the combined ear drops for the identification of IHF and MU. |
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Cuvinte-cheie Thin layer chromatography, isohydrafural, methyluracil, cromatografie pe strat subțire, izohidrafural, metiluracil |
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