Articolul precedent |
Articolul urmator |
428 16 |
Ultima descărcare din IBN: 2024-01-08 19:26 |
SM ISO690:2012 GUJA, Ecaterina, MAZUR, Ecaterina, UNCU, Livia. Compatibilitatea substanțelor active cu cele auxiliare în preparate medicamentoase . In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 667. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | |||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | |||||
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Pag. 667-667 | |||||
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Background. Auxiliary substances play an important role in the release of the active substance from the pharmaceutical form, due to their ability to change the drug bioavailability. They must be compatible with the active ingredients, without altering their pharmacological effect. Objective of the study. Comparative evaluation of physico-chemical factors and their impact in the selection process of auxiliary substances for the development of fixed-dose combinations. Material and Methods. Advanced bibliographic study of 71 bibliographic sources from databases: Medline, Scopus, HINARI, PubMed, Cochrane Electronic. Results. The analysis of the evaluated bibliographic sources shows the existence of physico-chemical interactions between the drug and the excipient. About 89% of the authors apply compatibility studies by spectral and thermal methods to detect interactions and select the optimal excipients. To improve the dissolution rate of drugs formulated in solid dispersions (example: Piroxicam, Ibuprofen) it is recommended to use polyethylene glycol with different molecular weight. In most of the evaluated sources (99%) the selection of excipients is made according to the physicochemical properties of the active principles. Conclusion. The research will serve as a basis for developing the method for selecting excipients in the preformulation process of a pharmaceutical product in the form of a polycomponent powder |
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Cuvinte-cheie compatibility, excipients, physico-chemical factors, compatibilitate, excipienți, factori fizico-chimici |
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