Articolul precedent |
Articolul urmator |
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Ultima descărcare din IBN: 2023-06-12 14:46 |
SM ISO690:2012 DRUMEA, Maria, VALICA, Vladimir, STÎNGACI, Eugenia. Sinteza și studiul preclinic al unui nou derivat nesaturat al 1,2,4 - triazolului cu acțiune antifungică. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 662. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 662-662 | ||||||
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Rezumat | ||||||
Background. Dermatomycoses are the most common fungal infections. Azoles and their derivatives are drugs intended for the treatment of fungal infections, the basic criterion in their synthesis being the sensitivity of fungi. Objective of the study. Synthesis, preclinical analysis study, determination of species sensitivity: Aspergillus fumigatus (A.fum.) and Aspergillus versicolor (A.v.) compared to Nitrotriazon – antifungal triazole derivative. Material and Methods. IR, UV spectroscopy, CSS, HPLC. NCCLS M38 standardized methods for determining the sensitivity of A.fum., A.v. Standardized fungal species; standard ketoconazole (st.); bifonazole (st); Nitrotriazon – for analysis. Results. The method of obtaining the compound Nitrotriazon was optimized and its physico-chemical properties were studied. The minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) in mM were determined. For Nitrotriazon: A.fum. and A.v: MIC=0,10 and MFC=0,19; Ketoconazol: A.fum. and A.v: MIC=0,38 and MFC=0,94; Bifonazol: A.fum: MIC=0,48; A.v: MIC=0,32; And MFC=0,64 for A.fum, A.v. Conclusion. The MIC and MFC indices indicate that Nitrotriazone possesses a more pronounced therapeutic activity than standard substances. Long-term azole therapy causes resistance, so obtaining new antifungal agents with minimal side effects remains relevant. |
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Cuvinte-cheie Nitrotriazon, antifungal, Aspergillus, species sensitivity, Nitrotriazon, antifungic, Aspergillus, sensibilitatea speciilor |
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