Norlabdane Compounds Containing Thiosemicarbazone or 1,3-Thiazole Fragments: Synthesis and Antimicrobial Activity
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BLAJA, Svetlana, LUNGU, Lidia, KUCHKOVA, Kaleria, CIOCARLAN, Alexandru, BARBA, Alic, VORNICU, Nicoleta, ARICU, Aculina. Norlabdane Compounds Containing Thiosemicarbazone or 1,3-Thiazole Fragments: Synthesis and Antimicrobial Activity. In: Chemistry of Natural Compounds, 2021, nr. 1(57), pp. 101-110. ISSN 0009-3130. DOI: https://doi.org/10.1007/s10600-021-03292-3
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Chemistry of Natural Compounds
Numărul 1(57) / 2021 / ISSN 0009-3130

Norlabdane Compounds Containing Thiosemicarbazone or 1,3-Thiazole Fragments: Synthesis and Antimicrobial Activity

DOI: https://doi.org/10.1007/s10600-021-03292-3

Pag. 101-110

Blaja Svetlana1, Lungu Lidia1, Kuchkova Kaleria1, Ciocarlan Alexandru1, Barba Alic1, Vornicu Nicoleta2, Aricu Aculina1
 
1 Institute of Chemistry,
2 Metropolitan Center of Research TABOR, The Metropolitanate of Moldavia and Bukovina
 
Disponibil în IBN: 8 aprilie 2021


Rezumat

New di-, tri-, tetra-, and pentanorlabdane compounds with thiosemicarbazone and 1,3-thiazole fragments were synthesized. Their antifungal and antibacterial activities were studied. The main advantages of this research were the available starting material, i.e., the natural labdane diterpenoid (–)-sclareol, which was isolated from renewable resources, and the high probability of biological activity combined with the low toxicity of these compounds because of their natural origin. 

Cuvinte-cheie
1, 3-thiazoles, Antimicrobial activity, norlabdane compounds, synthesis, Thiosemicarbazones