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| Ultima descărcare din IBN: 2023-07-25 17:02 |
| Căutarea după subiecte similare conform CZU |
| 616.98:578.823.91-053.3 (1) |
| Boli transmisibile. Boli infecţionase şi contagioase, stări febrile (585) |
| Virologie (442) |
 SM ISO690:2012DONOS, Ala, ALSALIEM, Tatiana, SPÎNU, Constantin, REVENCO, Ninel, TSURYA, Valentin, MIHU, Ion, COJOCARU, Radu, GHEORGHIŢA, Stela, SPÎNU, Igor, ILIEV, Albina-Mihaela, SUVEICĂ, Luminiţa. Comparative assessment of clinical-paraclinical manifestations of rotavirus infection versus genotypical variety in infants. In: One Health and Risk Management, 2021, nr. 2(2), pp. 42-50. ISSN 2587-3458. DOI: https://doi.org/10.38045/ohrm.2021.2.06 |
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| One Health and Risk Management | ||||||
| Numărul 2(2) / 2021 / ISSN 2587-3458 /ISSNe 2587-3466 | ||||||
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| DOI:https://doi.org/10.38045/ohrm.2021.2.06 | ||||||
| CZU: 616.98:578.823.91-053.3 | ||||||
| Pag. 42-50 | ||||||
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Introduction. RVI (rotavirus infection) is the most common cause of dehydration in infants and young children. The implementation of the sentinel surveillance of RVI in infants from 2008 in the Republic of Moldova demonstrated the high rate of this infection (40.0%), being an argument in recommending the antirotaviral immunization in children within the National Immunization Program. Material and methods. The study enrolled 193 children with acute diarrheal disease, included in the sentinel supervision (2012-2016) and treated in the Unit for Acute Diarrheal Diseases at Children’s Clinical Hospital no. 1. The biological material was examined by serological enzyme-linked immunosorbent assay (ELISA) and genotyping, revealed by polymerase chain reaction (PCR). Results. The rotavirus infection was confirmed in 193 infants, of which 121 children were not vaccinated against RVI, and 72 were immunized. Depending on the genotypes encountered before and after vaccination, it was found that G9P [8], G3P[8], G4P[8] were detected before vaccination, although postvaccine prevailed G2P[4], G4P[8]. In addition, the incidence of RVI is decreasing and the disease evolution is much better. Conclusions. This article reflects the evolution of the genotypic properties of rotaviruses and the clinical-paraclinical particularities of RVI in infants, highlighting the importance of the implementation of antiretroviral immunization in children within the National Immunization Program in the Republic of Moldova. |
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| Cuvinte-cheie diarrhea, rotavirus, children, infants, vaccine, infecţie rotavirală, sugar, genotip, vaccin |
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<?xml version='1.0' encoding='utf-8'?> <oai_dc:dc xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:oai_dc='http://www.openarchives.org/OAI/2.0/oai_dc/' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd'> <dc:creator>Donos, A.A.</dc:creator> <dc:creator>Alsaliem, T.</dc:creator> <dc:creator>Spînu, C.I.</dc:creator> <dc:creator>Revenco, N.E.</dc:creator> <dc:creator>Ţurea, V.M.</dc:creator> <dc:creator>Mihu, I.I.</dc:creator> <dc:creator>Cojocaru, R.</dc:creator> <dc:creator>Gheorghiţa, S.</dc:creator> <dc:creator>Spînu, I.</dc:creator> <dc:creator>Iliev, A.</dc:creator> <dc:creator>Suveică, L.N.</dc:creator> <dc:date>2021-04-07</dc:date> <dc:description xml:lang='en'><p>Introduction. RVI (rotavirus infection) is the most common cause of dehydration in infants and young children. The implementation of the sentinel surveillance of RVI in infants from 2008 in the Republic of Moldova demonstrated the high rate of this infection (40.0%), being an argument in recommending the antirotaviral immunization in children within the National Immunization Program. Material and methods. The study enrolled 193 children with acute diarrheal disease, included in the sentinel supervision (2012-2016) and treated in the Unit for Acute Diarrheal Diseases at Children’s Clinical Hospital no. 1. The biological material was examined by serological enzyme-linked immunosorbent assay (ELISA) and genotyping, revealed by polymerase chain reaction (PCR). Results. The rotavirus infection was confirmed in 193 infants, of which 121 children were not vaccinated against RVI, and 72 were immunized. Depending on the genotypes encountered before and after vaccination, it was found that G9P [8], G3P[8], G4P[8] were detected before vaccination, although postvaccine prevailed G2P[4], G4P[8]. In addition, the incidence of RVI is decreasing and the disease evolution is much better. Conclusions. This article reflects the evolution of the genotypic properties of rotaviruses and the clinical-paraclinical particularities of RVI in infants, highlighting the importance of the implementation of antiretroviral immunization in children within the National Immunization Program in the Republic of Moldova.</p></dc:description> <dc:description xml:lang='ro'><p>Introducere. IRV (infecţie rotavirală) este cauza cea mai frecventă de deshidratare la sugar şi la copilul mic. Implementarea în Republica Moldova în anul 2008 anul 2008 a supravegherii santinelă a IRV la sugari a relevat o rata înaltă a infecţiei (40,0%), acest fapt servind ca argument în recomandarea imunizării antirotavirale a copiilor în cadrul Programului Naţional de Imunizări. Material şi metode. În studiu au fost incluşi 193 de copii sugari cu boală diareică acută, aflați sub supravegherea santinelă în perioada 2012-2016 şi trataţi în Secţia de boli diareice acute a Spitalului Clinic Municipal de Copii nr. 1. Materialul biologic s-a examinat prin metoda reacţiei serologice ELISA, iar evidenţierea genotipurilor a fost efectuată prin reacţia de amplificare genică PCR. Rezultate. Dintre cei 193 de sugari cu infecţie rotavirală, 121 nu au fost vaccinaţi contra IRV, iar 72 – au fost imunizaţi. În funcţie de genotipurile întâlnite până şi după vaccinare, s-a constatat că până la vaccinare au predominat genotipurile G9P[8], G3P[8], G4P[8]. În schimb, postvaccinal au prevalat genotipurile G2P[4], G4P[8], incidenţa IRV fiind în scădere, iar evoluţia bolii – mult mai uşoară. Concluzii. Acest articol reflectă evoluţia proprietăţilor genotipice ale rotavirusurilor şi a particularităţilor clinico-paraclinice ale IRV la sugari, cu o importanţă majoră în contextual procesului de implementare a imunizării antirotavirale a copiilor în cadrul Programului Naţional de Imunizări din Republica Moldova.</p></dc:description> <dc:identifier>10.38045/ohrm.2021.2.06</dc:identifier> <dc:source>One Health and Risk Management 2 (2) 42-50</dc:source> <dc:subject>diarrhea</dc:subject> <dc:subject>rotavirus</dc:subject> <dc:subject>children</dc:subject> <dc:subject>infants</dc:subject> <dc:subject>vaccine</dc:subject> <dc:subject>infecţie rotavirală</dc:subject> <dc:subject>sugar</dc:subject> <dc:subject>genotip</dc:subject> <dc:subject>vaccin</dc:subject> <dc:title>Comparative assessment of clinical-paraclinical manifestations of rotavirus infection versus genotypical variety in infants</dc:title> <dc:type>info:eu-repo/semantics/article</dc:type> </oai_dc:dc>
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