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SM ISO690:2012 GAIDARJI, Olga. Rolul capilaroscopiei în evaluarea pacienților cu Fenomen Raynaud. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 570. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. Raynaud's Phenomenon (RP) is an episodic reaction to cold or stress, manifested as a change in extremity skin color. There are two types of RP. Primary RP is due to functional changes in the vessels, while secondary is due to endothelial injury in the context of systemic diseases. Objective of the study. Assessment of capillaroscopy role for the differentiation of primary and secondary Raynaud's Phenomenon in children Material and Method. A search was conducted in PubMed database with the following search-terms: ”Raynaud phenomenon in children”, ”Pediatric Raynaud phenomenon”, ”Capillaroscopy in children”, ”Capillaroscopy in childhood”. A specialized literature review was made to assess the existing data on the evaluation and monitoring of Raynaud phenomenon in children. Results. RP is reported as a first symptom of rheumatic disease in 61-70% of patients with systemic sclerosis, 58% of patients of patients with mixed connective tissue disease and 56% of patients with overlap syndrome. Therefore, the differentiation of primary RP from secondary RP as well as detecting the markers that suggest its progression to connective tissue diseases could facilitate early diagnosis of these diseases. Capillaroscopy is a simple, non-traumatic and cost-efficient tool with a major role in the differentiation of RP based on the capillaries look. Normal aspect suggests primary RP while altered shape and density – the presence of a connective tissue disease. Conclusion. The application of capillaroscopy for differential diagnosis between primary and secondary Raynaud phenomenon in children for an early diagnosis of rheumatic conditions could shed light on new pathogenetic and evolutive aspects, but also on the treatment response |
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Cuvinte-cheie capillaroscopy, children, endothelial injury, capilaroscopie, copii, injurie endotelială |
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