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Ultima descărcare din IBN: 2023-01-24 16:15 |
SM ISO690:2012 GLAVAN, Danu, GASNAŞ, Alexandru, GROPPA, Stanislav. Imunomodularea post-accident vascular cerebral (AVC) ischemic. mecanisme și implicații terapeutice. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 356. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. Inflammation of brain tissue after ischemic stroke leads to local and systemic effects. Suppression of immunity by the nervous system would result in the protection of nerve tissue from subsequent inflammatory damage. At the same time, it increases the susceptibility of the whole body to infections. Objective of the study. Description of local and systemic immune changes that occur after an ischemic stroke, outlining the mechanisms of immunosuppression induced by cerebral ischemia and the potential therapeutic implications of these phenomena. Material and Methods. Articles in English were searched on the PubMed Central and Google Scholar, using the keywords “ischemic stroke”, “inflammation”, “infection”, “immunomodulation”, “immunity” and “autoimmunity”. Representative papers were selected that provided data on pathogenetic pathways and inflammatory markers in ischemic stroke and their possible therapeutic approaches. Results. As an ischemic stroke occurs, an inflammatory cascade is triggered with cellular elements: neutrophils, microglia, monocytes/macrophages, T and B lymphocytes and humoral ones: cytokines, free radicals, damageassociated molecular pattern, autoantibodies, etc. These may be diagnostic and prognostic factors in ischemic stroke, as well as potential therapeutic targets for the control of ischemic injury and possible complications. One of the studied therapies, Fingolimod, a sphingosine-1-phosphate receptor modulator, which inhibits T lymphocytes, is shown to be promising by reducing the volume of infarction, the risk of hemorrhagic transformation and disability in Asians. Conclusion. Immunomodulatory therapy seems promising in certain subgroups of patients with ischemic stroke. By now there are modest data on the benefit of this therapy, collected from small populations, further studies which will help us select these subgroups being needed. |
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Cuvinte-cheie ischemic stroke, immunity, immunomodulation, inflammation, AVC ischemic, imunitate, imunomodulare, inflamație |
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