A pandemic is definitely a crisis. A crisis, says a cynical sentence, coming from economic sciences, is both a threat and an overtone window too. Despite of we don’t like this sentence, it has proved to be a reality. Therefore, in this essay, I will try to answer in short to the question: what are the opportunities opened by pandemic to bioethics? My attempt is mainly assessing the utility of principlism, a tool of medical ethics, in this context of public health. I will check the utility of principlism’s principles and their enhancement in our understanding for applying them. In conclusion, this essay will argue the usefulness of principlism in bioethics, and will point out the directions, revealed under “pandemic opportunity”, to be changed in order to increase our ability to apply this ethical tool, suggesting it could be extended to other domains of our current life.