Articolul precedent |
Articolul urmator |
376 7 |
Ultima descărcare din IBN: 2022-09-19 16:32 |
SM ISO690:2012 PAVLOVSCHI, Ecaterina. Dereglările activității catalazei în retinopatia hipertensivă. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 59. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
|
||||||
Pag. 59-59 | ||||||
|
||||||
Descarcă PDF | ||||||
Rezumat | ||||||
Background. The pathobiochemical mechanism of hypertensive retinopathy (HR) is with certainty not established. High blood pressure by itself could not explain the retinal changes that occur, therefore additional pathogenetic mechanisms, such as oxidative stress / antioxidant system imbalance, could be involved. Objective of the study. The study was designed to determine serum catalase (CAT) levels, a marker of oxidative stress / antioxidant balance and to identify whether there is a correlation between catalase levels and degree of HR. Material and Methods. 90 patients primarily detected with HR, divided according to the Keith-Wagener classification into GI-40 with HR grade I, GII-32 with HR grade II and GIII-18 with HR grade III. CAT activity was determined according to Koroliuk M. in the modification of Gudumac V. et al. (1996) and expressed as M ± DS. Analysis of variance (ANOVA) was used and p<0.05 statistically significant. Results. There was a tendency for CAT activity to increase in the blood of patients with hypertension as HR progressed. The CAT level in GII increased compared to GI (+ 8%; 34.88 ± 8.91 μM / L vs. 32.37 ± 8.52 μM / L, p = 0.381), as well as in patients in GIII compared to GII (+ 11%; 38.67 ± 17.35 μM / L vs. 34.88 ± 8.91 μM / L, p = 0.152). The CAT level did not show a correlation with the HR degree (r = 0.057; p = 0.293). CAT is responsible for neutralizing peroxides generated under conditions of oxidative stress. The maintenance of activity at a normal level may attest the minor involvement of peroxides in retinal damage in hypertension. Conclusion. The increase in the severity of hypertensive retinopathy is not correlated with increased serum catalase activity. Therefore, further studies are needed to conclude the role of the oxidative stress / antioxidant system balance in the development of hypertensive retinopathy. |
||||||
Cuvinte-cheie catalase, oxidative stress, antioxidant system, hypertensive retinopat, catalaza, stres oxidativ, sistem antioxidant, retinopatie hipertensivă |
||||||
|