Articolul precedent |
Articolul urmator |
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Ultima descărcare din IBN: 2023-09-13 22:03 |
SM ISO690:2012 PANTEA, Valeriana, POPA, Veaceslav, FULGA, Ala, ŞVEŢ, Inna, TAGADIUC, Olga. Modificările enzimei glutation peroxidazei în serul sanguin la administrarea unor compuși coordinativi autohtoni. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 50. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. Testing of new remedies to correct the redox imbalance are of particular interest. In this aspect an important role is assigned to glutathione peroxidase - the key enzyme, maintaining the optimum level of which is essential to life and characterizes the endurance capacity of an organism. Objective of the study. is the investigation of the influence of some new copper coordination compounds (CC) on the GPx activity in blood serum, the estimation and selection of the most effective compounds that could be used for improvement the antioxidant protection. Material and Methods. The action of CC - CMJ-33, CMT-67, TIA-3 and TIA-160 was evaluated in experiments on white female rats after subcutaneous administration of 1,0 μM/kg body weight, 3 times a week for 30 days. The evaluation of serum GPx was performed by Warburg test using the microplate Synergy H1 Hybrid Multi-Mode Reader (BioTek Instruments, USA). Results. The administration of CC has led to a moderate increase in GPx activity in blood serum. In administering the CMJ-33 compound, the GPx activity (UI/L) increased to 701.5, CMT-67 to 695.1, TIA-3 to 678.8 and TIA-160 to 701.5 comparative with control values 607.4. Conclusion. The copper coordination compounds - CMJ-33, CMT-67, TIA3 and TIA-160 have the property of stimulating the GPx activity, that fact to argues that further research is needed to obtain new biological active substances, which are raw materials for the pharmaceutical industry |
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Cuvinte-cheie copper coordination compounds, serum glutathione peroxidase., Compuși coordinativi ai cuprului, glutation peroxidaza serică |
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