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Ultima descărcare din IBN: 2022-11-13 18:35 |
SM ISO690:2012 LABLIC, Anastasia, FEGHIU, Iuliana, BALTAGA, Ruslan. Aritmogeneza indusă de medicamente la pacienții cu covid-19. Reviu al literaturii. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 42. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Rezumat | ||||||
Background. Several existing medications are being repurposed for treatment of COVID-19, including chloroquine and hydroxychloroquine. The use of these medications has been associated with QT prolongation. Their use in patients with COVID-19, magnifies the risk for development of heart arrhythmias. Objective of the study. The aim of this bibliographic research was to perform an analysis of existing clinical reports regarding effects of drugs used in patients with COVID-19 on myocardial repolarization, effects which can be measured on ECG as dispersion of QT interval. Material and Methods. A three‐step approach was employed. Firstly, a search of clinical reports in HINARI and PubMed using key words COVID-19 and QT dispersion was performed. Secondarily, selected articles were limited to the English language and human studies. Finally, full texts of all the selected articles were reviewed in details and points relevant to QT dispersion related to use of drugs were extracted. Results. The literature search identified 15 articles. After title and abstract screening, as well as language selection 11 papers were selected for full‐text review; all represented retrospective cohort study. The main findings of these studies were: (1) the use of chloroquine/hydroxychloroquine and azithromycin led to a significantly greater increase in the corrected QT interval when compared to monotherapy with either chloroquine or hydroxychloroquine, (2) prolongation of the QT only led to premature discontinuation of these medications and (3) there were no instances of arrhythmogenic death. Conclusion. Medications used in COVID-19 patients have the potential to affect electrophysiology of the heart and can be associated with QT dispersion on ECG. Giving importance to these ECG markers may have a significant contribution in decreasing drug-related arrhythmias in this group of patients. |
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Cuvinte-cheie QT dispersion, COVID-19, dispersia intervalului QT, COVID-19 |
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