Articolul precedent |
Articolul urmator |
295 2 |
Ultima descărcare din IBN: 2024-03-06 23:57 |
SM ISO690:2012 BUGAI, Rodica. Evaluarea riscului relativ estimat al unor factori de risc în pancreatita cronică. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 189. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 189-189 | ||||||
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Rezumat | ||||||
Background. Chronic pancreatitis (PC) is a multifactorial pathology, involving exogenous and endogenous, genetic and non-genetic factors. The rather high incidence and prevalence of PC in the heterogeneous population of the RM imposes the need to study the estimated relative risk of some common risk factors. Objective of the study. Determination of the estimated relative risk (OR) within the 95% confidence interval (CI) of conventional risk factors for CP. Material and Methods. The study included 100 patients with CP, mean age-47,02±0,93, m/f-55/45. Estimated relative risk (OR) in the 95% confidence interval (CI) of some risk factors for CP (mutations R122C/PRSS1, R117H/CFTR, N34S/SPINK1, alcohol, smoking, hypertriglyceridemia, family history (FH) of CP) was determined by using the parametric modeling system. Results. A relatively high estimated risk (OR) has been demonstrated in people who consume alcohol-23, 22, 95% CI (8,18-71,04), χ2=57,17, p<0,001. Smoking has an OR of 9,41, 95% Cl (3,91-23,45), χ2= 33,27, p<0,001; hypertriglyceridemia-OR=66,00, 95% CI (9,36-1339,01), χ2=44,30, p<0,001, FH of CP-OR=3,84, 95% CI (1,99-7,46); R117H/CFTR in heterozygotes-OR=2,59, 95% Cl (1,30-5,25), χ2=7,53, p<0,01, homozygotes-OR=5,24, 95% Cl (2,0413,73), χ2=13,61, p<0,001; R122C/PRSS1 in homozygotes-OR=15,03, 95% Cl (3,08-99,29), χ2=16,02, p<0,001; N34S/SPINK1 in homozygotes-OR=5,47, 95% Cl (1,93-15,94), χ2=11,74, p=0,001. Conclusion. There is a high estimated relative risk (OR) in the 95% confidence interval (CI) for CP risk factors: alcohol, hypertriglyceridemia, smoking, FH of CP, genetic markers, especially in the homozygous variant, more obviously in the case of mutation R122C/PRSS1. |
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Cuvinte-cheie chronic pancreatitis, risk factors, estimated relative risk (OR), pancreatită cronică, factori de risc, risc relativ estimat (OR) |
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