Introduction. Bacterial resistance to antibiotics is a complex phenomenon that defines the ability of microorganisms to survive and multiply in the presence of an antibiotic. This natural process for bacteria threatens to reach an unprecedented extent.   Aim of the study. To evaluate the incidence of pathogenic flora in hospital conditions and the degree of microbial resistance in hospitalized patients.   Materials and methods. The retrospective study carried out within the "Sfînta Treime" Municipal Clinical Hospital comprises a group of 30 patients hospitalized in Therapy II. The study included medical records of patients hospitalized between April and July 2017, aged between 30 and 70 years. The antibioticograms and the treatment of these patients have been studied and interpreted.   Results. The study showed a prevalence of bacterial culture of Streptococcus viridans representing 30% cases, followed by Streptococcus beta haemolyticus and Staphylococcus aureus in 20%, Staphylococcus haemolyticus - 13.33%, E. Coli - 6, 66%. Moxarella catarhalis, Streptococcus pyogenes and Klebsiella oxytoca in a proportion of 3.33% are less significant. The isolated microorganisms from patients in Therapy II section showed increased resistance to antibiotics in the penicillin group - 73.33%, the macrolide group - 36.66%, the glycopoid group -26.66%, and the cephalosporins group - 16.66 %. Less bacterial resistance is for quinolone groups -10.00%, fenicols - 6.66%, oxozolidones, aminoglycosides and penicillins + beta-lactamase inhibitors in equal proportions of 3.33%.   Conclusions. The study of antibiotic resistant pathogenic flora from patients in Therapy II section showed a prevalence of bacterial culture of Streptococcus viridans, followed by Streptococcus beta haemolyticus and Staphylococcus aureus. Microorganisms isolated from these patients showed increased resistance to antibiotics in the penicillin groups, followed by macrolides, glycopeptides and cephalosporins.