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|Neurologie. Neuropatologie. Sistem nervos (459)|
| SM ISO690:2012|
CĂLCÎI, Cornelia; HADJIU, Svetlana; SPRINCEAN, Mariana; LUPUŞOR, Nadejda; FEGHIU, Ludmila; REVENCO, Ninel; GROPPA, Stanislav. Dificultăți in abordarea statusului epileptic refractar in populația pediatrică. In: Buletin de Perinatologie. 2020, nr. 4(89), pp. 16-20. ISSN 1810-5289.
|Buletin de Perinatologie|
|Numărul 4(89) / 2020 / ISSN 1810-5289|
Objective. Status epilepticus (SE) is a life-threatening neurological emergency requiring immediate medical intervention and is associated with high mortality and morbidity. Methods: The study was done between January 1, 2017 and December 24, 2019. All children with the age limits mentioned above, who presented convulsive epileptic status (SE), subsequently with development in RSE (refractory status epileptic), were included in the study. Patients were investigated and evaluated according to a standard protocol. Subsequently, the characteristics of children with RSE and those without an evolution in RSE were compared. Results: 55 children, out of whom 32 boys with SE were enrolled in the study, of which 20 children (36%) developed RSE. CNS infections were the most common causes in SE and development of RSE (51% in SE and 53% in RSE, p > 0.05). Noncompliance of antiepileptic medication served as the second cause for evolution in RSE. Th e overall mortality rate was 10.9%, the chances of death in RSE (20%) being higher than in SE (5.7%). Th e unfavorable prognosis was seven times higher in children with RSE, compared to children who developed SE (PR = 7.0; 95% CI :1.6-22.3). Conclusions: In the management of CNS infections, pediatricians should be aware of the high risk of developing RSE. In addition, the possibility of developing RSE should be considered and promptly managed in an intensive care unit in order to reduce the risk of mortality and morbidity of this severe neurological condition.
refractory status epilepticus, childhood epilepsy, CNS infection,
рефрактерный эпилептический статус, детская эпилепсия, инфекция ЦНС