A fost apreciat statutul imun humoral la 44 de pacienţi cu tuberculoză pulmonară, care au fost repartizaţi în 3 grupe: disbioză de gradu 1 – 13 bolnavi; gradul 2 -11 bolnavi şi gradul 3 -20 bolnavi. La toţi pacienţii a fost studiat subclasele de imunoglobuline A, M, G, nivelul complexelor imune circulante, concentraţia ALAT şi ASAT, indexul intoxicaţiei Kalf-Kalif şi indexul leucocitar al reactivităţii imune. S-a demonstrat că în dependenţă de gradul disfuncţiei microbiocenozei intestinale se agravează indicii statutului imun umoral, fermenţii ALAT şi ASAT. La bolnavii cu disfuncţie intestinală de gradul 3 s-a depistat cele mai vădite dereglări ale statutului imun şi funcţiei de detoxicare ale fi catului.

Characteristics of humoral immunity and intestinal dysbiosis in patients with pulmonary tuberculosis The aim of the study was to asses the immune status in 44 patients with pulmonary tuberculosis. The patients were divided in 3 groups: 1st group – 13 patients with 1st degree intestinal dysbiosis, 2nd group – 11 patients with second degree of intestinal dysbiosis, and 3rd group – 20 patients with 3rd degree of intestinal dysbiosis. In all groups were evaluated levels of IgA, IgM, and IgG, immune complexes, ALT, AST, Kalf-Kalif indexes, the index of leucocytes immune reactivity. The statistical analysis of the data found a positive correlation between the degree of intestinal dysbiosis and the humoral status indices, as well as with ALT, AST levels. Patients with 3rd degree intestinal dysbiosis showed the most severe disturbances in the immune status and abnormalities in liver function.