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579.842.16:615.281.9.015.8 (1) |
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SM ISO690:2012 TAMBIC ANDRASEVIC, Arjana, ANTAL ANTUNOVIC, Ivana. The world-wide spread of carbapenem-resistant enterobacterales. In: One Health and Risk Management, 2021, nr. 2(1), pp. 4-12. ISSN 2587-3458. DOI: https://doi.org/10.38045/ohrm.2021.1.01 |
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One Health and Risk Management | ||||||
Numărul 2(1) / 2021 / ISSN 2587-3458 /ISSNe 2587-3466 | ||||||
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DOI:https://doi.org/10.38045/ohrm.2021.1.01 | ||||||
CZU: 579.842.16:615.281.9.015.8 | ||||||
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Introduction. Gram-negative bacilli belonging to the order Enterobacterales are normal inhabitants of the human gut, which also are the most common causative agents of both nosocomial and community acquired infections in patients of all ages. Although not even a century has passed since Fleming's discovery of penicillin, the scientists have been alarmed by the fact that the "last resort antibiotics" viz. carbapenems have been compromised. Ma-terial and methods. The analysis of fifty-two articles and documents regarding this topic was peformed. Results. The main mechanism of resistance to carbapenems in Enterobac-terales is production of carbapenemases, being enzymes that destroy all or almost all β-lactam antibiotics including carbapenems. According to Ambler’s classification β-lac-tamases can be distributed into four classes (A, B, C, and D) being based on primary amino acid sequence homology. The most important carbapenemases produced by Enterobacter-ales belong to class A (KPC), class B (metallo-β-lactamases NDM, VIM, IMP) and class D (OXA-48-like). Unlike other mechanisms of resistance, carbapenemase production is easily spread via plasmids making carbapenemase-producing Enterobacterales (CPE) a global challenge for healthcare providers. Conclusions. CPE are not readily detected in the labo-ratory but the ability to detect carbapenemase production in Enterobacterales has very im-portant infection control implications and therefore is essential for local infection control programs and national and international surveillance systems. Furthermore, local epide-miology of multidrug resistant organisms has major influence on development of national clinical guidelines for antimicrobial use. |
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Cuvinte-cheie car-bapenem resistant Enterobacterales, carbapenem-resis-tant Klebsiella pneu-moniae, carbape- nems, carbape-nemases, Enterobacterales car-bapenem rezistente, Klebsiella pneumo-niae carbapenem-re-zistentă, carbape-neme, cabapenemaze |
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