Background. Acne vulgaris is the formation of comedones, papules, pustules, nodules, and cysts as a result of obstruction and inflammation of pilosebaceous units( hair follicles and their accompanying sebaceous gland). This disease may be chronical with relapses. Case report. I have evaluated the method of ozone therapy on the patient with acne vulgaris diagnosis. Such patient had been treated traditionally with insignificant results. The schedule of visits and possible combinations at treatment were discussed with the parents of the patients (5 teens at the age 12-16). Basic course of treatment consisted of 10 procedures twice a week. Each procedure included local intradermal face injections {15 mg/ml} and droppers with ozone {6mg/ml}. The results became obvious after 4 procedures. The old elements were resorbed and new ones did not reappear. Remarkable aesthetic success was achieved after completing the full course. The amount of relapses were cut down. Conclusions. Taking account side effects of antibiotics, retinoid and hormonal drugs at the early age, it is necessary to think over the alternative methods of treatment witch one is ozone therapy. Ozone therapy is one of the best therapies easily accepted by patients leading to improve their individual and social life.