The purpose of this study is to analyze the regional macroeconomic indicators of the Northern Development Region of the Republic of Moldova, for a period of 5 consecutive years, 2013-2017. The North development region includes the municipality of Balti and 11 districts, with a stable population number of 974.6 thousand people, or approx. 27.5% of the total number of stable population in the republic. The economic-mathematical and analytical-comparative methods were applied to the research, and the official data of the National Bureau of Statistics of the Republic of Moldova were used as materials. The regional Gross Domestic Product in current prices from the study region, in 2017 was approx. 16.8% of GDP per country. During the analyzed period, the regional GDP of the region increased by ≈1.4% times, or by 9.1 billion MDL, from 21 billion MDL in 2013 to 30.1 billion MDL in 2017. GDP The regional value of the study region is composed of the total gross value added (≈86.6%) and net taxes on products (13.4%). The gross value added in the analyzed region, during the years 2013-2017, increased by ≈1.5 times, or by 8.1 billion MDL, from 18 billion MDL in 2013 to 26.1 billion MDL in 2017, the average being 22.1 billion MDL. Taxes on products increased by a slower step, ≈1.3 times, on average amounted to 3.4 billion MDL.The highest share in gross value added by economic activities has agriculture (on average 23%), followed by manufacturing (on average 14%) and wholesale and retail trade (on average 9%). At the same time, it is worth mentioning that some economic activities in the region increased at a faster step than the gross value added in the Northern Development Region, namely: other service activities (≈2.2 times), construction (≈1.8 times), trade (≈1.8 times), manufacturing (≈1.7 times), transport (≈1.7 times) and water distribution, sanitation, waste management (≈1.6 times).