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616.853-053.2:616.831-053.1-036 (1) |
Neurologie. Neuropatologie. Sistem nervos (971) |
SM ISO690:2012 HADJIU, Svetlana, CĂLCÎI, Cornelia, FEGHIU, Ludmila, CUZNEȚ, Ludmila, LUPUŞOR, Nadejda, GRÎU, Corina, SĂRĂTEANU, Ina, GAVRILUŢĂ, Iulia, SPRINCEAN, Mariana, REVENCO, Ninel. Epilepsia structurală la copiii cu antecedente perinatale hipoxic-ischemice: variabile predictive. In: Buletin de Perinatologie, 2020, nr. 3(88), pp. 42-48. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 3(88) / 2020 / ISSN 1810-5289 | ||||||
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CZU: 616.853-053.2:616.831-053.1-036 | ||||||
Pag. 42-48 | ||||||
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Introduction. The epilepsy (EP) is one of the leading condition in children who have had hypoxic-ischemic (HI) perinatal brain lesions (PBL). It can oft en be associated with mental retardation and oft en having an onset at an early age. Aim of the study is to determine the predictive variables in children with a history of HI PBL depending on the severity of the suff ering, to assess the risk of developing EP. Material and methods: Prospective study over a period of 2 years, on a group of 614 children, who had moderate (50.5%) and severe (49.5%) PBL. EP was diagnosed in 259 (42.2%) cases, the onset between 3 months and 2 years of age (peak 3-6 months), in children with moderate (27%) and severe (57.6%) PBL. We assessed some determinant variables for EP in the child aft er PBL based on a study protocol. Results. According to a logistic regression calculation, we determined the following variables with major risk in the development of EP in the child aft er PBL: (1) intrauterine hypoxia (p <0.001), (2) severe PBL at birth (p <0.006), (3 ) disorders of consciousness (p <0.003), (4) the presence of neonatal convulsions (p <0.004), (5) the pathological electroencephalographic pathway in the fi rst two weeks aft er birth (p <0.000). The probability of developing EP in the child who suff ered from PBL in the case of the combination of the 5 variables is high (RP + = 99.7%). Conclusions. The EP can develop at any age, especially in the child with severe PBL, the most vulnerable being the infant age. The association and number of predictive variables determine various individualized results. |
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Cuvinte-cheie epilepsy, perinatal brain lesions, variable, эпилепсия, перинатальные поражения мозга, факторы |
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<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xmlns='http://datacite.org/schema/kernel-3' xsi:schemaLocation='http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd'> <creators> <creator> <creatorName>Hadjiu, S.A.</creatorName> <affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Călcîi, C.</creatorName> <affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Feghiu, L.</creatorName> <affiliation>IMSP Institutul Mamei şi Copiluluii, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Cuzneț, L.</creatorName> <affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Lupuşor, N.</creatorName> <affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Grîu, C.</creatorName> <affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Sărăteanu, I.</creatorName> <affiliation>Spitalul Clinic Municipal nr. 1, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Gavriluţă, I.</creatorName> <affiliation>Spitalul Clinic Municipal nr. 1, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Sprincean, M.L.</creatorName> <affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Revenco, N.E.</creatorName> <affiliation>IMSP Institutul Mamei şi Copiluluii, Moldova, Republica</affiliation> </creator> </creators> <titles> <title xml:lang='ro'>Epilepsia structurală la copiii cu antecedente perinatale hipoxic-ischemice: variabile predictive</title> </titles> <publisher>Instrumentul Bibliometric National</publisher> <publicationYear>2020</publicationYear> <relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>1810-5289</relatedIdentifier> <subjects> <subject>epilepsy</subject> <subject>perinatal brain lesions</subject> <subject>variable</subject> <subject>эпилепсия</subject> <subject>перинатальные поражения мозга</subject> <subject>факторы</subject> <subject schemeURI='http://udcdata.info/' subjectScheme='UDC'>616.853-053.2:616.831-053.1-036</subject> </subjects> <dates> <date dateType='Issued'>2020-11-30</date> </dates> <resourceType resourceTypeGeneral='Text'>Journal article</resourceType> <descriptions> <description xml:lang='en' descriptionType='Abstract'><p>Introduction. The epilepsy (EP) is one of the leading condition in children who have had hypoxic-ischemic (HI) perinatal brain lesions (PBL). It can oft en be associated with mental retardation and oft en having an onset at an early age. Aim of the study is to determine the predictive variables in children with a history of HI PBL depending on the severity of the suff ering, to assess the risk of developing EP. Material and methods: Prospective study over a period of 2 years, on a group of 614 children, who had moderate (50.5%) and severe (49.5%) PBL. EP was diagnosed in 259 (42.2%) cases, the onset between 3 months and 2 years of age (peak 3-6 months), in children with moderate (27%) and severe (57.6%) PBL. We assessed some determinant variables for EP in the child aft er PBL based on a study protocol. Results. According to a logistic regression calculation, we determined the following variables with major risk in the development of EP in the child aft er PBL: (1) intrauterine hypoxia (p <0.001), (2) severe PBL at birth (p <0.006), (3 ) disorders of consciousness (p <0.003), (4) the presence of neonatal convulsions (p <0.004), (5) the pathological electroencephalographic pathway in the fi rst two weeks aft er birth (p <0.000). The probability of developing EP in the child who suff ered from PBL in the case of the combination of the 5 variables is high (RP + = 99.7%). Conclusions. The EP can develop at any age, especially in the child with severe PBL, the most vulnerable being the infant age. The association and number of predictive variables determine various individualized results.</p></description> <description xml:lang='ru' descriptionType='Abstract'><p>Введение. Эпилепсия (ЭП) является одним из основных заболеваний у детей, перенесших гипоксическиишемическое перинатальное повреждение головного мозга (ППГМ). Она часто может сочетаться с умственной отсталостью и в основном начинается в раннем возрасте. Цель: определить прогностические факторы у детей, перенесших ППГМ, в зависимости от тяжести заболевания, чтобы оценить риск развития ЭП. Материал и методы. Проспективное исследование в течение 2 лет группы из 614 детей, перенесших ППГМ средней (50,5%) и тяжелой (49,5%) степени. ЭП была диагностирована в 259 (42,2%) случаях, с началом в возрасте от 3 месяцев до 2 лет (пик 3-6 месяцев), у детей со средней (27%) и тяжелой (57,6%) ППГМ. Мы оценили некоторые определяющие переменные для ЭП у ребенка после ППГМ на основе протокола исследования. Результаты. Используя метод логистической регрессии, мы определили следующие наиболее важные факторы риска развития ЭП у ребенка после ППГМ: (1) внутриутробная гипоксия (р <0,001), (2) тяжелая степень ДЦП при рождении (р <0,006), (3) нарушения сознания (p <0,003), (4) наличие судорог у новорожденных (p <0,004), (5) патологические характеристики электроэнцефалографии в первые две недели после рождения (p <0,000). Вероятность развития ЭП у ребенка, перенесшего ППГМ, в случае комбинации 5 факторов высока (RP + = 99,7%). Выводы. ЭП может развиться в любом возрасте, особенно у детей с тяжелой формой ППГМ, наиболее уязвимым является грудной возраст. Сочетание различных прогностических факторов в разных комбинациях объясняет различные индивидуализированные результаты.</p></description> </descriptions> <formats> <format>application/pdf</format> </formats> </resource>