Transnational corruption is a specific form of global corruption and represents a major international economic, financial and social problem. The technical-scientific progress, the development of international financial infrastructure and the globalization process have created broad opportunities for this type of criminal activity. Corruption is considered transnational if the corrupt schemes involve both domestic participants and official (or executive) officers from abroad to obtain the right to carry out economic activity on the territory of a particular country or to obtain certain illegal advantages. It is represented through two aspects: international economic activity and the development of international organized crime. In the context of international economic activity transnational corruption intervenes in founding and organizing foreign-owned enterprises, mixed companies, in the implementation of investment projects, the privatization of public property, the development of specific import and export transactions. In the sphere of organized crime, transnational corruption encourages tax evasion, contributes to the functioning of the shadow economy and the implementation of money laundering schemes. As the financial potential of the international promoters of the corruption schemes is enormous, it contributes to the serious deterioration of the corruption situation in the Republic of Moldova, and the negative consequences for the economic development of the country are visible. Considering the above mentioned, it is necessary to combine the fight against corruption with the development of the respective cooperation of the Republic of Moldova with the international structures, as well as with the authorities of the other countries, including the European Union.