With an ageing population and strong competitive pressures from globalization, Europe's future economic growth and jobs will increasingly have to come from innovation in products, services and business models. Process innovation he was and remains a solution to the major challenges of society. At present, both a disruption of the classical world economy and the emergence of a new economy based on innovation and knowledge policy, capable of contributing to the resolution of the economic and financial crisis. Its inability to create new revolutionary new products and the delay in other dimensions of technical progress is not due to errors in politics, but is a specific property of the deeply rooted economic system. The Euroregions and cross-border areas must be responsive and define the rules of the game in order to create a prosperous innovation climate.