Introduction. Urolithiasis takes an important place in the structure of urological pathology, thanks to its high incidence, its recurrence frequency and the complications it might cause. There are many scientific publications dedicated to the study of urinary infection as an etiological factor of urolithiasis. Chronic pyelonephritis has the important etiologic and pathogenic role in the development of urolithiasis, but stone formation as a complication is possible in chronic inflammation of the upper and lower urinary tract. In some cases, urinary infection precedes the development of urolithiasis and may serve as a trigger for kidney stones formation. In other cases, it associated with urolithiasis, arising from other infectious causes. The association of metabolic factors and the infection usually forms chemically mixed renal stones containing phosphates, which in most cases are recurrent. In general, urinary tract infection is detected in 80% of cases of urolithiasis. Aim of the study. To improve the results of postoperative treatment of patients with chronic calculous pyelonephritis (CCP). Materials and methods. The study was performed on a group of patients with renal lithiasis treated in the Surgical Urology and Nephrology Clinic of the USMF "N. Testemitsanu", Republican Clinical Hospital between 2016 and 2017. In the study group were included 120 patients (men - 58, women - 62) aged between 23 and 70 years. Results. According to the results obtained from the research group, the stones’ solving methods were distributed in the following way: 55 patients (45.8%) - retrograde ureteroscopy, in 32 (26.7%) cases - pyelolithotomy; 19 (15.8%) cases - nephrolithotomy, in 8 (6.7%) patients received extracorporeal lithotripsy; and 6 patients (5.0%) - lithokinetic therapy with drug administration. Conclusions. Based on this study results we consider that the implementation and application of the proposed treatment method in the CCP improves the activation of cellular immunity and the restoration of humoral immunity, the rheological properties of the blood and as a result, improves the blood circulation in the affected kidney. In this context, the obtained results confirm the priority of combined therapy in CCP with phytotherapy and spasmolytic therapy compared to traditional therapy. It is important to underline that antibacterial therapy is mandatory and is administered in accordance with the antibiotic susceptibility testing.