The role of PRF in the treatment of trophic ulcers of lower limbs
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2022-11-09 14:52
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ZUGRAV, Tatiana. The role of PRF in the treatment of trophic ulcers of lower limbs. In: MedEspera: International Medical Congress for Students and Young Doctors, Ed. 7th edition, 3-5 mai 2018, Chişinău. Chisinau, Republic of Moldova: 2018, 7, pp. 113-114.
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Dublin Core
MedEspera
7, 2018
Congresul "International Medical Congress for Students and Young Doctors"
7th edition, Chişinău, Moldova, 3-5 mai 2018

The role of PRF in the treatment of trophic ulcers of lower limbs


Pag. 113-114

Zugrav Tatiana
 
”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 6 noiembrie 2020


Rezumat

Introduction. Tissue regeneration remains a current multidisciplinary issue. Up to 48% of patients with trophic ulcers are at age of maximum productivity. 67% of patients with trophic ulcers become disabled, and at 81% the quality of life considerably decreases. PRF (P latelet Rich Fibrin) membranes are a new perspective in tissue regeneration. Aim of the study. To evaluate the effect of fibrin enriched thrombocytes in tissue regeneration of the patients with trophic ulcers. Materials and methods. This prospective stud y, started in January 2017 and included 26 patients, divided into 2 groups: with small and medium sized lower extremities trophic ulcers with duration of 6 24 months without epithelial dynamics. I group 12 patients have used PRF membranes, including 7 (58. 3%) patients with chronic venous insufficiency, 3 (25%) with neuropathic ulcers and 2 patients (16.6%) with arterial ulcers. Out of the 14 patients of the control group, 6 (43%) had venous ulcers, 5 (35.7%) ulcers of neuropathic origin and 3 (21%) ulcers o f arterial origin. All patients received general and local basic treatment. The microbiological examination in dynamics was performed at all patients. PRF membranes were obtained by centrifugation of peripheral venous blood under special conditions. Resul ts. Complete epithelization at 10 months of treatment combined with PRF was achieved in 66.6% (8) patients. In the control group at 10 months of treatment complete epithelization was obtained in 50% (7) patients. The histological comparison between groups demonstrated neovascularization and PMN in I group compared to group II poor in granulation tissue. Conclusions. PRF is simple and accessible method to use. PRF membranes initiate and accelerate granulation tissue and angiogenesis. At PRF treated patients , full epithelization of ulcers occurs more rapidly.

Cuvinte-cheie
trophic ulcer, platelets, Regeneration, PRF