Climate warming inevitably entails a multidirectional effect on the ecological system as a whole and the biocenosis of winter wheat in particular, including the phytopathological situation. To create an original resistant material in the laboratory of breeding of intensive wheat varieties of Plant Breeding and Genetics Institute (Ukraine, Odessa), the interspecific crossing method is actively used. After a preliminary multi-year study of a collection of samples of carriers of resistance genes from wheat-related species, a series of crosses with the best of them, lines with high rates of resistant to diseases, early maturity, and grain quality were selected. The obtained stable genetic material as an indicative collection was transferred to the genetic resources sector of our Institute for further use in the breeding program, as well as to the National Center for Plant Genetic Resources of Ukraine.