Applicability of eular/acr classification criteria for idiopathic inflammatory myopathies
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LOGHIN-OPREA, Natalia. Applicability of eular/acr classification criteria for idiopathic inflammatory myopathies. In: MedEsperaInternational Medical Congress for Students and Young Doctors. 7, 3-5 mai 2018, Chişinău. Chisinau, Republic of Moldova: 2018, pp. 93-94.
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MedEspera
7, 2018
Congresul "International Medical Congress for Students and Young Doctors"
7th edition, Chişinău, Moldova, 3-5 mai 2018

Applicability of eular/acr classification criteria for idiopathic inflammatory myopathies


Pag. 93-94

Loghin-Oprea Natalia
 
”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 3 noiembrie 2020


Rezumat

Introduction. Till recently, the most widely used criteria for the diagnosis of idiopathic inflammatory myopathies (IIM) autoimmune diseases characterised by muscle weakness and muscle inflammation was done the Bohan and Peter criteria, which has a high sensitivity (94,3%), but low sp ecificity (29,4%). The International Myositis of Assessment and Clinical Studies Group (IMACS) created a new criteria set that shows better performance than the existing ones. Aim of the study. To evaluate the performance of new criteria in patients with i diopathic inflammatory myopathies. Materials and methods. A cross sectional study was done on patients with idiopathic inflammatory myopathies, during May 2016 december 2017. Clinical and demographic data was collected based on a special questionnaire made by us and according to international recommendation on IIM. The ACR/EULAR criteria set has 16 variables from 6 categories, each has an assigned weight (score) based on its influence to discriminate IIM from non IIM. The sum of all scores provides a corres ponding probability of having IIM, the level 55 90 % is for probable IIM and ≥90% is for definite disease. The study was accepted by the Bioethical Committee of SUMPh ” Nicolae Testemitanu” from 23 may 2016. Results. The study group consisted of 65 patient s, the majority of them were Caucasian females, W:M ratio was 3.3:1. The median age at the examination was 52.9±13.1 (range 25 78) years versus 48.5±11.1 at the onset of the disease. Regarding the mean duration of the disease, we determined it was 113.8±68 .8 (iv 6 324) months. Applying the new set of criteria we determined that the mean number of criteria was 7.21±1.46, varying from 5 to 11 criteria, equivalent to 91.4±14.5 percent, which represents a defined diagnosis. Age at onset of first symptom ≥ 18 an d < 40 years was determined in 35.4 % and more than 40 years had 64.6 % of study patients, specific for these diseases. Weakness of proximal upper extremities, usually progressive over time was appreciated in 98.5 % and of lower extremities 95.4 percent. S kin manifestation were represented by heliotrope rash observed in 33 (50.7%) patients and Gottron’s papules 24 (36.9%) cases. The presence of dysphagia was detected in 11 (16.9%) patients and anti Jo 1 antibodies were found in 5 (7.7%) cases. It should be noted that the elevation of muscle enzymes were present in all patients. Muscle biopsy, optional in the new criteria, was done by 22 (33.8 %) patients and characteristic features were observed, the most frequent was endomysial infiltration of mononuclear c ells surrounding, but not invading myofibres in 16 (24.6 %) cases. Conclusions. The new criteria set for the diagnosis and classification of idiopathic inflammatory myopathies is easy to apply and interpret, being useful in examining these patients.

Cuvinte-cheie
idiopathic inflammatory myopathies, Diagnosis, clasification