Introduction. Recent electroencephalography (studies in epilepsy patients with myoclonic seizures have revealed distinctictal and interictal discharges that rely on structurally and functionally interconnected cortical and/or subcortical networks. However, the neuroanatomical substrates in this type of seizures are insufficiently characterized. Aim of the study. To explore the EEG patterns and associated cortical and subcortical (structural abnormalities in epilepsy patients with myoclonic seizures. Material and methods. For this purpose, were performed EEG recordings and brain magnetic resonance imaging (in 11 epilepsy patients (24 6 years; 3 males) with myoclonic seizures and 11 healthy subjects (28 4; 6 males). The MRIs were processed using FreeSurfer cross se ctional stream and the between group differences in cortical thickness ( and thalamic volumes assessed. Results. Interictal EEG revealed polyspike waves in 27% of patients and spike slow waves in 37% and no discharges in 36% of patients. The frequency o f discharges was 3.5 Hz in 27%, 2.5 3.5 Hz in 36% and 2.5 Hz in 9% of patients. Intermittent slow waves were recorded in 37% of patients and EEG background asymmetry in 9%. Photoparoxysmal response was obtained in 82% of patients. The analysis of ict al EEG disclosed generalized patterns: polyspike waves in 45% of patients, spike slow waves in 28%, spike slow waves with a frequency of 3 Hz in 18% and of 2 Hz in 9% of patients. A statistically significant difference (p 0.001, uncorrected) of CT wa s found in the following clusters: left postcentral, supramarginal and rostral middle frontal cortices, and right lateral occipital, rostral middle frontal, supramarginal, pars triangularis and insular regions. CT correlated with the disease duration in th e left superior, middle and inferior temporal and inferior parietal cortices, and right supramarginal, inferior parietal and rostral anterior cingulate cortices. Thalamic volumes in patients(right 7078.5 508.7/left 7804.1 737.4 mm3) compared to healthy subjects(right 8155.9 702.1/left 9168.1 1442.5 mm3) were significantly lower(p 0.014, p 0.001, respectively). Conclusions. Ictal EEG patterns were relevant in all epilepsy patients with myoclonic seizures, while interictal EEG discharges only in 6 4% of patients. Alterations of CT along with bilateral thalamic volume loss support the hypothesis of involvement of aberrant cortico thalamic networks in patients with myoclonic seizures.