Introduction. Although rare, alterations of the cranial nerves can be detected at any stage of the clinical evolution of non-Hodgkin lymphomas. The lesions can be focal or/and isolated of varying degrees of damage. The routine neurological examination of cranial nerves in Lymphoma patients can spot apparently minor involvement of cranial nerves. Aim of study. The purpose of the research was to reveal any involvement of cranial nerves in non-Hodgkin lymphoma patients. Materials and methods. Clinical neurological examination, electrophysiological examination, CT or MRI study, lumbar puncture and rarely the puncture of the nerves enlargement were performed in 83 non-Hodgkin lymphoma patients morphologically confirmed. The descriptive statistics is used. Results. 39.8% (33patients) of the entire group of examined patients had clinical manifestation of cranial nerves lesion. The odor change was registered in 12 patients, flagrant optic nerve damage was established in only 1 case, oculomotor nerves injury in 3 patients, another 3 patients manifested the clinical signs of the damage of the trochlear nerve, the various degree of sensitive alteration, predominantly in the territory of the second branch of the trigeminal nerve was registered in 4 patients. Facial nerve impairment, confirmed by electrophysiology was diagnosed in 5 patients. Unilateral hearing loss of pure lymphomatous origin was registered in 2 patients. Swallowing difficulties and change of the voice modulation were recorded in 3 patients. Multiple cranial nerve lesions were counted registered in 7 cases. Most cranial nerves alterations occurred in non-Hodgkin's lymphoblastic lymphoma, derived from Type B cells. Lumbar puncture usually did not detect the presence of the lymphoma cells in the cerebrospinal fluid. The MRI or CT examination in the majority of the cases confirmed an infiltration process or compression, usually lightly involving with radiotherapy treatment. Conclusions. The damage of the cranial nerves in non-Hodgkin lymphomas in the current study was mostly cause by infiltration or constriction. All nerves can be affected isolated or in group. The prognosis is usually poor and is resistant to classical existing treatments.