Introduction. The pathogenesis of diabetes type II and obesity is based on a mix of genetic factors, disorders of the immune balance and lifestyle factors. С ombination of this pathological processes increases the risk of vascular complications and becomes a significant social and economic problem of mankind. This negative trend requires a detailed examin ation of all possible causes of chronic inflammation, which is one of the key factors in kidney failure progression. Aim of the study. To evaluate the indicators: interleukin 1(IL 1), interleukin 6(IL 6), and transforming growth factor β 1(TGF β 1) in patie nts with diabetic nephropathy(DN) and obesity. Materials and methods. For the study 43 patients with diabetes type II were selected, aged between 41 63 years, with at least 10 years duration of the disease. Glomerular filtration rate ( in all patien ts was not less than 90 ml/min. All patients were divided into two groups: group 1 included patients with DN stage III without concomitant obesity (22 people), the 2nd group included patients with DN stage III and I degree obesity (21 people). The control group consisted of 22 healthy subjects. Exclusion criteria: courses of antibiotic therapy of any duration for the last 4 weeks, cancer. In addition to general clinical methods of examination, all patients underwent determination of IL 1, IL 6 and TGF β 1 levels. Results. Analysis of clinical and laboratory parameters examined patients showed increasing levels of IL 1, IL 6 and TGF β 1 compared with those parameters of healthy subjects(p < Levels of proinflammatory cytokines were higher in patients wit h concomitant obesity. Conclusions. The analysis of clinical and laboratory parameters revealed the presence of an imbalance in immunogram in obese and non obese patients with chronic kidney disease. However, the changes in patients with II degree obesity were more significant. In this same group the patients showed a more pronounced impairment of renal function, indicating a more severe course of disease in obese patients. It means that this variant of the disease is more unfavorable.