A fost elaborat un algoritm de diagnostic al formaţiunilor nodulare tiroidiene, care cuprinde examenul clinic, scintigrafi c, ecografi c şi citologic prin puncţie ecoghidată. A fost demonstrată importanţa investigaţiilor imunohistochimice şi electronomicroscopice în diagnosticul formaţiunilor tiroidiene şi în aprecierea gradului de diferenţiere a carcinoamelor de tiroidă. În tratametnul chirurgical al pacienţilor cu patologie nodulară a glandei tiroide, cele mai adecvate şi organomenajante s-au dovedit a fi operaţiile extrafasciale, care au asigurat ablastia şi radicalitatea, păstrându-se, totodată, funcţia hormonală a ţesutului tiroidian restant şi calitatea bună a vieţii. Operaţiile organomenajante realizate au permis obţinerea unei rate de supravieţuire de 5 ani la 98,7% pacienţi. Prin aprecierea indicilor de sensibilitate şi specifi citate ale diferitor metode investigative, a fost elaborat un algoritm de diagnostic al patologiilor nodulare tiroidiene. Au fost elaborate noi procedee chirurgicale, cu scopul prevenirii complicaţiilor postoperatorii şi ameliorarea tratamentului cancerului tiroidian.

It was elaborated a diagnostic algorithm of thyroid nodules, that included clinical examination, scintigraphy, ultrasound and cytology examination by punction. It was demonstrated the importance of immunohystochemy and electron microscopy in diagnosis of thyroid nodules and in appreciation of differentiation degree of thyroid carcinoma. Regarding the surgical treatment of patients with nodular pathology of thyroid gland, the most adequate and conservative surgery was proved to be extrafascial operation, which assure ablation and radicalism. Such operation preserves hormonal function of thyroid tissue and good quality of life, allows to obtain a survival rate at 5 years to 98,7% of patients. On the basis of sensibility and specifi city of different methods of investigation was elaborated an algorithm of diagnosis of thyroid nodular pathology. It was elaborated new surgical proceedings to prevent postoperative complications and to improve the thyroid cancer treatment.