Din 1240 de cazuri de limfom Hodgkin, la 57 (4,5%) de bolnavi au fost depistate tumori secundare maligne. La 5 pacienţi dezvoltarea lor a fost sincronă. În 6 cazuri limfomul Hodgkin s-a dezvoltat metacron faţă de alte trei tumori primare solide şi trei maladii limfoproliferative cronice. În 46 de cazuri tumorile secundare maligne s-au dezvoltat după 3-30 ani de la tratamentul limfomului Hodgkin. Numai la un pacient după 3,5 ani de la tratamentul combinat chimioradioterapeutic s-a diagnosticat leucemie acută mieloblastică. La ceilalţi 45 de bolnavi s-au dezvoltat tumori secundare solide. Localizarea lor a fost variată şi, de regulă, nu a depins de caracterul şi zonele iradiate anterior. La fi ecare al cincilea bolnav s-au înregistrat câte 2-3 tumori secundare maligne, majoritatea din ele caracterizându-se prin rezistenţă la tratamentul administrat.

The second malignant tumors were revealed in 57 (4,5%) cases of 1240 Hodgkin’s disease patients. In 5 cases the concomitant development of them was present. In another 6 cases Hodgkin’s disease was a metachronous neoplasm as to three primary solid tumors and three chronic limphoprolipheratic diseases. The second malignant tumors developed in 46 Hodgkin’s disease patients 3-30 years after being treated. Only one patient of these had acute myeloblastic leukemia 3.5 years after Hodgkin’s disease treatment with chemo- radiotherapy. The second solid malignancies were present in the remaning 45 patients. Their localization was various and did met depend on the character and fi eld of the undergone irradiation. Four Hodgkin’s disease patients had 2-3 second tumors each. Most of the cases did not comply with the administered therapy.