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SM ISO690:2012 ISAEV, E.. Резистентность к клопидогрелю и активность тромбоцитов у больных с острым инфарктом миокарда с подъемом сегмента ST. In: Curierul Medical, 2012, nr. 1(325), pp. 24-28. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 1(325) / 2012 / ISSN 1875-0666 | ||||||
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Pag. 24-28 | ||||||
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Among 60 patients with ST elevated acute myocardial infarction (MI), receiving dual antiplatelet therapy with aspirin (300 mg) and clopidogrel (300 mg), have been identified in patients with clopidogrel resistance and patients with normal response to clopidogrel. The expanded biochemical analysis was carried out upon admission to the hospital. The platelet count, MPV value, PCТ and PDW were measured simultaneously. The comparative analysis
of biochemical values and results of the medical treatment in different groups of patients didn’t shown significant difference. Average platelet aggregation in patients at 24th hour was 447 ± 214 AU*min. In the resistant group this value was 612 ± 159 AU*min, and in non-resistant group 282 ± 108 AU*min. The analysis of platelet count, middle platelet volume (MPV), PCT and PDW showed significant differences in platelet count in clopidogrel-resistant patients (300 ± 67 x 10^3/mm3) and in patients with normal response to treatment (259 ± 53 x 10^3/mm3) (p = 0.019). The significant difference in MPV value in research groups was also revealed. In patients with normal response to clopidogrel this value was 9.3 ± 1 fl, while in clopidogrel-resistant group
it was 8.5 ± 0.9 fl (p = 0.003). As a result of our research in patients with acute STEMI receiving dual antiplatelet therapy, we identified the important role of platelet count and MPV values for early diagnostics and in defining the algorithm of antiplatelet treatment.
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Cuvinte-cheie acute myocardial infarction, average platelet volume, resistance to clopidogrel |
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