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618.3-06:616.853-085 (1) |
Științe medicale. Medicină (11141) |
Neurologie. Neuropatologie. Sistem nervos (971) |
SM ISO690:2012 HOVANSCAIA, Diana, SERBENCO, Eduard, GROPPA, Stanislav. Complicațiile fetale la gravidele cu epilepsie. In: Buletin de Perinatologie, 2020, nr. 1(86), pp. 48-52. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 1(86) / 2020 / ISSN 1810-5289 | ||||||
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CZU: 618.3-06:616.853-085 | ||||||
Pag. 48-52 | ||||||
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Epilepsy itself and uncontrolled seizures during pregnancy have been associated with obstetric adverse eff ects fetal loss, fetal hypoxia, neurodevelopmental disorders. Exposure to antiepileptic drugs is the main cause of the substantial increase in the risk of delayed intrauterine development of the fetus, premature birth with small head for gestational age, minor and major congenital malformations, mental retardation or postnatal neurocognitive dysfunctions, fetal and perinatal mortality. Th e risk of these complications depends on the type, number and dose of anti-pyeseptic drugs administered: the risk is lower in monotherapy compared to polyterapy and lower dose management compared to larger doses. Maximum risk of teratogenicity for major congenital malformations, cognitive impairment and autistic spectrum, constant and signifi cantly associated with valproate, administered both in monotheraphy and in polytheraphy Maintaining a balance between the control of epileptic convulsions and the potential teratogenic eff ects of the MFA is fundamental to the treatment of pregnant women with epilepsy |
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Cuvinte-cheie epilepsy, pregnancy, birth seizures, antiepileptic drugs, fetal complications, congenital malformation, эпилепсия, беременность, роды, конвульсии, противоэпилептические препараты, материнские осложнения, осложнения плода |
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