The 1,2,4-triazole compounds are considered interesting heterocycles since they possess
important pharmacological activities1. The results of investigations devoted to the synthesis of
new homodrimane compounds containing triazole structural units are reported.The
homodrimane with triazoleunits derivatives 5-8were prepared from the intermediate
carbothioamides3, 4 under basic conditions. The carbothioamides3, 4 in turn, were prepared
from commercially available sclareolide1, in 2 steps (scheme 1).

The antimicrobial and antifungal activities of the compounds 3-8 were assessed by
performing “in vitro” tests against five species of fungi (Aspergillus niger, A. flavus,
Penicillium chrysogenum, P. frequentans, Alternaria alternata)and two species of bacteria
(Pseudomonas aeroginosaandBacillus sp.).2 Compounds3 and 6 showed a good antifungal
activity,at the MIC 0.125μg/mL,and respectively0.094 μg/mLand antibacterial activity, atthe
MIC 0.064μg/mL,and respectively0.047 μg/mL.
The structures of compounds 3-8 were established on the basis of their 1H, 13C and
2DNMR data.
References:
[1]. K. Rajasekhar Reddy, et al. Synthesis and Antimicrobial Activities of Some Triazole, Thiadiazole, and Oxadiazole
Substituted Coumarins. J. Hetercyclic Chem., 2014, 51, 132-137.
[2]. National Committee on Clinical Laboratory Standards (NCCLS), “Antimicrobial Susceptibility Standards (ATS)”, ed.
2003, for M7 (CMI) and M100.