Generating Diversity in Natural Product Scaffolds. Synthesis of ent-Kauranic Derivatives Functionalized with Triazole Fragments

Gîrbu Vladilena; Grinco Marina; Ungur Nikon; Kulciţki Veaceslav; Renaud Philippe

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2023-11-21 21:42

SM ISO690:2012

GÎRBU, Vladilena, GRINCO, Marina, UNGUR, Nikon, KULCIŢKI, Veaceslav, RENAUD, Philippe. Generating Diversity in Natural Product Scaffolds. Synthesis of ent-Kauranic Derivatives Functionalized with Triazole Fragments. In: Medical Plants – present and perspectives: Dedicated to the 60-year celebration of the „Stejarul” Biological Research Centre, 6-9 septembrie 2016, Piatra Neamț. Piatra Neamț, România: NIRDBS/„Stejarul“ Biological Research Centre, 2016, Ediția a 12-a, pp. 144-145. ISSN Print ISSN: 1223-6578 Online ISSN: 2247-2711.

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Medical Plants – present and perspectives
Ediția a 12-a, 2016

Simpozionul "Medical Plants – present and perspectives"
Piatra Neamț, Romania, 6-9 septembrie 2016

Generating Diversity in Natural Product Scaffolds. Synthesis of ent-Kauranic Derivatives Functionalized with Triazole Fragments

Pag. 144-145

Gîrbu Vladilena¹², Grinco Marina¹, Ungur Nikon¹², Kulciţki Veaceslav¹², Renaud Philippe³

¹ Institute of Chemistry of the Academy of Sciences of Moldova,
² University of the Academy of Sciences of Moldova,
³ University of Bern

Disponibil în IBN: 6 august 2020

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Rezumat

The current work presents the first results on the application of the radical hydroazidation
methodology for the functionalization of ent-kaurenic derivatives which represent an important family
of natural diterpenoids with relevant biological activities. Following conversion of obtained azide to
different triazoles containing hybrids was acheived via a click-chemistry procedure involving several
alkynes.

Cuvinte-cheie
Hydroazidation, click reaction, radical chemistry, diterpenes