Thiosemicarbazones are currently well established as an important class of sulphur donor
ligands particularly for transition metal ions. These compound containing thione (C=S) and thiole
(C-S) groups occupy an important position among organic reagents as potential donor ligands for
transition metal ions [1-3].
In this work we report the syntheses, structure and characterization of copper(II)
coordination compounds with thiosemicarbazones 2-methyl -1H-imidazole-4-carbaldehyde (1)
and thiosemicarbazones 4-methyl -1H-imidazole-5-carbaldehyde (2) containing dichloroacetate
anion (Fig.1). The complexes were synthesized by reacting ligand with the metal ions in 1:1 molar
ratio in an ethanolic medium. The complexes were identified and characterized by elemental
analyses, IR and electronic spectral studies also by X-ray diffraction. Copper (II) ions are
coordinated via NNS donor atoms at the thiosemicarbazone fragment and O from carboxylate
ligand. The mononuclear unit is assembled in dimer via O from carboxylate ligand. The complexes have pyramidal geometry.
Fig.1 Crystal structure of the synthesized compounds
The antimicrobial activity against gram-negative and gram-positive bacteria have
been determined for this compounds. Newly synthesized molecules exhibited good
antimicrobial activity against bacterial species.
References
1. S. Padhye, G.F. Kauffman, Coord. Chem. Rev. 63, 127–160, 1985
2. D.X. West, S.B. Padhye, P.B. Sonawan, Structure&Bonding ,76, 1-50, 1991
3. E. W. Ainscough, A.M. Brodie, W.A. Denny, G.J. Finlay, J. D.Ranford, J. Inorg.Biochem.,
70(3-4), 175–185, 1998.